Emma Lefrancais on Alarmin IL33 and Platelet Biology
Emma Lefrancais, Scientific Researcher at CNRS, shared on LinkedIn:
”I’m delighted to share the publication of Lucie Gelon PhD work, available online at Blood Advances, uncovering a key role for the IL-33/ST2 axis in platelet biology:
“The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis”
Although platelets do not express IL-33, our study shows that IL-33 profoundly shapes their production and function.
We demonstrate that IL-33/ST2 signaling:
• remodels the platelet proteome, enriching inflammatory proteins
• impairs platelet adhesion and thrombus formation when absent
• accelerates platelet production in the lung by promoting megakaryocyte fragmentation within the vasculature
These mechanisms are likely to be particularly relevant during stress and aging, when IL-33–responsive megakaryocyte precursors expand.
Huge congratulations to Lucie Gelon for this great work at IPBS-Toulouse (CNRS-UT3), and many thanks to all co-authors and collaborators, Stéphane Roga, Jean-Philippe Girard, Anne Gonzalez de Peredo and Edith Vidal and Sonia SEVERIN!”
Read the full article here.
Article: The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis
Authors: Lucie Gelon, Stéphane Roga, Anne Gonzalez-de-Peredo, Edith Vidal, Jean-Philippe Girard, Sonia Severin, Emma Lefrançais
Stay updated on all scientific advances with Hemostasis Today.
-
Mar 17, 2026, 18:11Ossama Mansour: Landmark MENA Guidelines for Acute Ischemic Stroke Management
-
Mar 17, 2026, 17:48Andrea Van Beek: Improving DOAC Adherence Saves Lives
-
Mar 17, 2026, 17:43Soumen Bhattacharyya: Microangiopathic Hemolytic Anemia Is Often a Hematologic Clue to Underlying Malignancy
-
Mar 17, 2026, 17:37Peter Bou Dib: New Insights on Factor VIII and the Musculoskeletal System
-
Mar 17, 2026, 17:31Armghan Ans: The 2026 Stroke Guidelines Are Excellent, Now the Hard Part
-
Mar 17, 2026, 17:26Danny Hsu: Navigating a Rebalanced Hemostatic State in Decompensated Cirrhosis
-
Mar 17, 2026, 17:21Matías J Alet on Acute Ischemic Stroke With Low NIHSS at NeuroQuality
-
Mar 17, 2026, 17:16S1PR4 Controls Platelet Fibrinogen Binding and Thrombus Formation – JTH
-
Mar 17, 2026, 15:55Mostafa Faisal Mohammed Saleh: Evidence-Based Recommendations for Hodgkin Lymphoma Management in LMICs