Alan Nurden: A “Gold Medal” Study on Silk Fibroin 3D Models for Bone Marrow Fibrosis
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared a post on LinkedIn, about a recent article by Julia B. Kral-Pointner et al, published in Wiley Online Library:
“A most intelligent and well thought out study that confirms the silk fibroin 3D-model for studying the expression of functional mesenchymal stromal cells (MSCs) under different conditions and matrix scaffold stiffness. But beware, it is not an easy read!
Congratulations to Alessandra Balduini and her colleagues.
Here they apply their model to the study of bone marrow fibrosis. But the potential applications of their method, and in particular when applied to the study of megakaryocyte maturation in inherited disorders of platelets (and I suggest the gray platelet syndrome where marrow fibrosis is a problem) are endless.
As the Winter Olympics in Italy have started, I give it a gold medal.”
Title: Thermo-Chemically Modified Silk Scaffolds Reveal Niche-Driven Regulation of Hematopoiesis and Fibrosis
Authors: Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini
Read the Full Article on Wiley Online Library.
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