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Tumor Type Determines Thrombotic and Bleeding Risk in Cancer-Associated VTE – RPTH Journal
RPTH Journal
Feb 19, 2026, 12:47

Tumor Type Determines Thrombotic and Bleeding Risk in Cancer-Associated VTE – RPTH Journal

RPTH Journal shared a post on LinkedIn about a recent article by Olga Gavín Sebastián et al, adding:

“Not all cancer-associated VTE behaves the same. And this study proves it!

We often treat cancer-associated thrombosis as one disease.

But what if the type of cancer dramatically changes the balance between clotting and bleeding?

A large RIETE registry analysis of 4,721 women with breast, ovarian, or uterine cancer and VTE delivers a powerful message:

The clinical course of VTE is cancer-specific.

Here’s what stood out

  • Ovarian cancer – most thrombotic
    Highest VTE recurrence rate: 7.29 per 100 patient-years
  • Uterine cancer – most bleeding
    Highest major bleeding rate: 11.1 per 100 patient-years
    Higher fatal bleeding and mortality
  • Breast cancer – lowest overall risk
    Recurrence: 2.70 per 100 patient-years
    Major bleeding: 2.73 per 100 patient-years

In multivariable analysis:

  • Ovarian cancer: higher VTE recurrence and mortality
  • Uterine cancer: higher recurrence, bleeding risk, and mortality

Translation:
The ‘one-size-fits-all’ anticoagulation approach in cancer may no longer be enough.

This study makes a strong case for tumor-specific anticoagulation strategies and future trials stratified by cancer type.

Big questions for the community:

  1. Should anticoagulation guidelines become cancer-type specific?
  2. Could tailored dosing or drug choice improve outcomes?
  3. Are we underestimating bleeding risk in uterine cancer?”

Title: Venous thromboembolism in patients with breast, ovarian, and uterine cancer. A comparative analysis from the Registro Informatizado Enfermedad TromboEmbólica registry

Authors: Olga Gavín Sebastián, Javier Trujillo-Santos, María del Carmen Díaz-Pedroche, Pablo Demelo-Rodríguez, Sonia Otálora, Benjamin Brenner, José María Pedrajas, Alessandra Bura-Riviere, Luis Hernández-Blascom, Manuel Monreal

Read the Full Article on RPTH.

Tumor Type Determines Thrombotic and Bleeding Risk in Cancer-Associated VTE - RPTH Journal

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Alessandra Bura-Riviere Benjamin Brenner Breast Cancer Cancer VTE Health Hematology Hemostasis Hemostasis News Hemostasis Today Javier Trujillo-Santos José María Pedrajas Luis Hernández-Blascom Manuel Monreal María del Carmen Díaz-Pedroche Medicine Olga Gavín Sebastián ovarian cancer Pablo Demelo-Rodríguez RPTH Journal Sonia Otálora Uterine cancer VTE
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