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The Results of Landmark COBRRA Trial in Acute VTE Management – ISTH
Lana Castellucci/Everyday Health
Mar 11, 2026, 22:01

The Results of Landmark COBRRA Trial in Acute VTE Management – ISTH

International Society on Thrombosis and Haemostasis (ISTH) shared a post on LinkedIn about a recent article by Lana Castellucci et al, published in NEJM:

”If you attended ISTH2025, you may have had the chance to hear about the COBRRA trial during our late-breaking research session!

COBRRA is the FIRST head to head trial of apixaban vs rivaroxaban in the management of acute VTE.

We’re thrilled to see that the full study has been published by NEJM Group!

Join us in congratulating Lana Castellucci on this groundbreaking work and read the article.”

Title: Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism

Authors: Lana A. Castellucci, Vivien M. Chen, Michael J. Kovacs, Alejandro Lazo-Langner, Peter Greenstreet, Susan Kahn, Benoit Côté, Sam Schulman, Kerstin de Wit, James Douketis, Deepa Suryanarayan, Tony Wan, Erik Yeo, Genevieve Le Templier, Huyen A. Tran, Abbey Willcox, Helen J. Crowther, Ritam Prasad, Sudeep Shivakumar, Etimbuk Umana, Fionnuala Ni Ainle, Tobias Tritschler, Stefano Barco, Jean-Philippe Galanaud, Marc Blondon, Lisa Baumann Kreuziger, Susan Solymoss, Clive Kearon, Erin Thomas, Tim Ramsay, Gregoire Le Gal, Marc Rodger,  for the COBRRA Trial Investigators

Read the Full Article on NEJM

The Results of Landmark COBRRA Trial in Acute VTE Management - ISTH

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Abbey Willcox Alejandro Lazo-Langner Apixaban Benoit Côté Clive Kearon COBRRA Deepa Suryanarayan DVT Erik Yeo Erin Thomas Etimbuk Umana Fionnuala Ní Áinle Genevieve Le Templier Gregoire Le Gal Health Helen J. Crowther Hematology Hemostasis Hemostasis News Hemostasis Today Huyen A. Tran ISTH James Douketis Jean-Philippe Galanaud Kerstin de Wit Lana A. Castellucci Lana Castellucci Lisa Baumann Kreuziger Marc Blondon Marc Rodger Medicine Michael J. Kovacs NEJM Peter Greenstreet Ritam Prasad Rivaroxaban Sam Schulman Stefano Barco Sudeep Shivakumar Susan Kahn Susan Solymoss thrombosis Tim Ramsay Tobias Tritschler Tony Wan Vivien M. Chen VTE
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