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Ahmet Dirican: Apixaban vs Rivaroxaban in Acute VTE
Ahmet Dirican/X
Mar 13, 2026, 16:51

Ahmet Dirican: Apixaban vs Rivaroxaban in Acute VTE

Ahmet Dirican, Professor of Medical Oncology at Medicana International İzmir Hospital, shared a post on X about a recent article by Lana A. Castellucci et al, published in The New England Journal of Medicine:

”New NEJM trial: Apixaban vs Rivaroxaban in acute VTE

Clinically relevant bleeding:

Apixaban 3.3%

Rivaroxaban 7.1%

RR 0.46

  • Similar efficacy for recurrent VTE
  • Significantly lower bleeding with apixaban

However, an important limitation: Cancer-associated thrombosis patients were excluded from the trial.

So there is no direct evidence in oncology patients. Still, in daily oncology practice — especially in patients with higher bleeding risk — this signal may be worth keeping in mind when choosing between DOACs.”

Title: Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism

Authors: Lana A. Castellucci, Vivien M. Chen, Michael J. Kovacs, Alejandro Lazo-Langner, Peter Greenstreet, Susan Kahn, Benoit Côté, Sam Schulman, Kerstin de Wit, James Douketis, Deepa Suryanarayan, Tony Wan, Erik Yeo, Genevieve Le Templier, Huyen A. Tran, Abbey Willcox, Helen J. Crowther, Ritam Prasad, Sudeep Shivakumar, Etimbuk Umana, Fionnuala Ni Ainle, Tobias Tritschler, Stefano Barco, Jean-Philippe Galanaud, Marc Blondon, Lisa Baumann Kreuziger, Susan Solymoss, Clive Kearon, Erin Thomas, Tim Ramsay, Gregoire Le Gal, Marc Rodger

Read the Full Article on The New England Journal of Medicine

Ahmet Dirican: Apixaban vs Rivaroxaban in Acute VTE

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Abbey Willcox Ahmet Dirican Alejandro Lazo-Langner Apixaban Benoit Côté bleeding bleeding disorders Cancer patients Clive Kearon Deepa Suryanarayan Erik Yeo Erin Thomas Etimbuk Umana Fionnuala Ní Áinle Genevieve Le Templier Gregoire Le Gal Health Helen J. Crowther Hematology Hemostasis Hemostasis News Hemostasis Today Huyen A. Tran James Douketis Jean-Philippe Galanaud Kerstin de Wit Lana A. Castellucci Lisa Baumann Kreuziger Marc Blondon Marc Rodger Medicine Michael J. Kovacs Peter Greenstreet Ritam Prasad Rivaroxaban Sam Schulman Stefano Barco Sudeep Shivakumar Susan Kahn Susan Solymoss Tim Ramsay Tobias Tritschler Tony Wan Vivien M. Chen
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