Jim Hoffman։ Targeting NETosis to Help Autoimmune and Post-Infection Syndromes
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, shared Robert Bransfield’s post on LinkedIn, adding:
”Great interview and video cast with Nikki Schultek, a leading pathobiome researcher, describing her chronic struggle with post-acute infection illness.
Virtually everything she discusses cries out for a therapy capable of controlling chronic low to high-grade ‘NETosis dysregulation.’ Hyper-NET induction and impaired NET clearance in response to infection and other triggers can exacerbate both infectious and non-infection-related illnesses.
If you are concerned about the overuse of antibiotics, immunosuppressants and systemic administration of other drugs to treat chronic and periodic acute proinflammatory autoimmune flares, we should be considering periodic extracorporeal NET removal therapy as an alternative strategy that has been shown to put severe drug-refractory autoimmune flares into remission. If used earlier in the course of treatment, it may be of greater benefit before irreversible loss of organ functions occurs and could help preserve the healthy microbiome that is damaged by prolonged antibiotic use, without also immunosuppressing the immune system with high-dose steroids and other unwanted drug-related side effects.
Research suggests removing NETs will likely provide enormous symptom relief and put chronic disease severity in remission longer than current systemic drug treatments, and could do this regardless of the triggering event, be it infectious, non-infectious, or a comorbid combination in origin. Like underlying pathogenic infections, cancer is also suspected of triggering autoimmune encephalitis.
Please watch Nikki Schultek’s story and Erin Nicole’s video describing her 539-day intensive care hospitalization, undergoing many very expensive invasive treatments and diagnostic procedures in an attempt to save her life from what may have been due to ovarian cancer, causing severe brain encephalopathy. This autoimmune encephalopathy has recently been linked to ‘NETosis dysregulation’, as are many other neurodegenerative and mental health issues.
Erin Nicole’s battle with anti-NMDR Encephalopathy.
NETosis dysregulation/NETosis induction by the plasma’s of these Anti-NMDA Receptor Encephalitis patients.
Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis.”
Robert Bransfield shared a post on LinkedIn:
”This is a very interesting interview of Nikki Schultek, Director of Alzheimer’s Pathobiome Initiative, and her colleague Brian Balin. It begins at 6 minutes.”
Title: Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis
Authors: Shan Qiao, Quan-ye Sun, Peng Zhou, Shan-chao Zhang, Zhi-hao Wang, Hai-yun Li, Ai-hua Wang, Xue-wu Liu, Tao Xin
Read the Full Article on Frontiers in Immunology
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