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Mohammed Alo: Can Atherosclerosis Progress Even with a Zero Calcium Score
Mohammed Alo/LinkedIn
Apr 19, 2026, 13:27

Mohammed Alo: Can Atherosclerosis Progress Even with a Zero Calcium Score

Mohammed Alo, Fellow of the American College of Cardiology at American College of Cardiology, shared a post on LinkedIn about a recent article by Guiomar Mendieta et al., published in JACC Journals:

“When using 3DVUS to look inside the arteries of young people, 88% of those whose plaque progressed had a calcium score of 0.

In those whose plaque progressed, the percentage that still had a CAC of 0 was still 76%.

This shows us again that CAC is a much later stage finding.

You can have plenty of soft plaque without calcium.

The study also showed that those whose disease progressed were the oldest and those with the highest LDL-C.”

Title: Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years

Authors: Guiomar Mendieta, Stuart Pocock, Virginia Mass, Andrea Moreno, Ruth Owen, Inés García-Lunar, Beatriz López-Melgar, Jose J. Fuster, Vicente Andres, Cristina Pérez-Herreras, Hector Bueno, Antonio Fernández-Ortiz, Javier Sanchez-Gonzalez, Ana García-Alvarez, Borja Ibáñez,Valentin Fuster

Mohammed Alo: Can Atherosclerosis Progress Even with a Zero Calcium Score

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3DVUS Ana García-Alvarez Andrea Moreno Antonio Fernández-Ortiz Atherosclerosis Beatriz López-Melgar Borja Ibáñez CAC Calcium Cristina Pérez-Herreras Guiomar Mendieta Hector Bueno Inés García-Lunar JACC Journals Javier Sanchez-Gonzalez José J. Fuster Mohammed Alo Ruth Owen Stuart Pocock Valentin Fuster Vicente Andres Virginia Mass
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