Rashad Mohamed: What Does ‘Capping’ Mean in Anticoagulant Dosing?
Rashad Mohamed, Icu Registrar at Imam Abdulrahman Al Faisal Hospital, shared a post on LinkedIn:
“What does ‘Cap’ mean in dosing?
In anticoagulation context (e.g.,Rashad Mohamed for PE):
Dose capping: putting a maximum fixed upper limit on the dose, even if the weight-based calculation gives a higher number.
Example: Patient weighs 180 kg 1 mg/kg results in 180 mg BID.
If someone ‘caps’ the dose at 150 mg results in patient receiving less than weight-based dose.
In morbid obesity, major guidance (e.g., International Society on Thrombosis and Haemostasis and American College of Chest Physicians) supports using actual body weight and does not recommend routine capping, unless there is a specific bleeding concern.
Why avoiding capping matters: Underdosing results in increased risk of treatment failure, increased risk of recurrent PE.”
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