Dima Shulkin: How Neutrophil Extracellular Traps Shape ACS
Dima Shulkin, Co-Founder and CTO at RobotDreams GmbH, shared a post on LinkedIn about a recent article by Yawen Wu et al, published in Journal of Inflammation, adding:
“Most discussions about acute coronary syndrome (ACS) are still pleasantly mechanical.
A plaque ruptures, a clot forms, the artery closes.
Which is true, but also a little too tidy.
This review on neutrophil extracellular traps, or NETs, is a good reminder that ACS is not just a plumbing problem.
It is also a white blood cell problem.
The basic idea is simple.
Neutrophils, one of our first responder immune cells, can release web-like structures made of DNA, histones, and granular proteins. In infections, that can be useful.
In coronary disease, it gets awkward.
The paper describes how these NETs may contribute to plaque destabilization, endothelial injury, platelet adhesion, coagulation, and thrombus growth.
In other words, they seem to sit right at the intersection of inflammation and thrombosis, which is exactly where ACS becomes dangerous.
What I like about this review is that it makes neutrophils harder to dismiss as just ‘another elevated inflammatory cell count.’
The argument is more specific.
Activated neutrophils may actively shape the event itself, before, during, and after coronary occlusion.
Paper: Wu et al. Neutrophil extracellular traps in acute coronary syndrome. Journal of Inflammation, 2023.”
Title: Neutrophil extracellular traps in acute coronary syndrome
Authors: Yawen Wu, Shilin Wei, Xiangyang Wu, Yongnan Li, Xue Han
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