Moustafa Abdou/LinkedIn
May 13, 2026, 14:33
Moustafa Abdou: Could a Commonly Prescribed Drug Trigger Life-Threatening Hemolysis?
Moustafa Abdou, Author and Founder of AskHematologist.com, shared a post on LinkedIn:
“Could a commonly prescribed drug trigger life-threatening hemolysis in your patient?
G6PD deficiency is one of the most common enzymatic disorders worldwide, yet it continues to be under-recognised in day-to-day clinical practice.
The real challenge is not diagnosis alone, but anticipating and preventing hemolytic triggers, particularly in acute care and oncology settings.
Key clinical insights:
- Oxidative stress from infections or drugs can precipitate acute hemolysis.
- Certain medications, including rasburicase, can lead to severe complications if G6PD deficiency is unrecognised.
- Peripheral blood smear may reveal bite cells and blister cells during hemolytic episodes.
- Enzyme testing can be misleading during acute hemolysis and may require repeat confirmation.
- In this updated article, I summarise the pathophysiology, triggers, diagnostic pitfalls, and practical management considerations for G6PD deficiency:
A practical refresher for clinicians involved in prescribing, acute care, and hematology.”
Other posts featuring Moustafa Abdou on Hemostasis Today.
-
Jun 27, 2026, 18:19Nabil Tabish: The Paradox of Zero – Investigating Extreme VWF Discordance
-
Jun 27, 2026, 18:19Francesco Favruzzo: Can Mechanical Thrombectomy Be Safely Used in Cervical Artery Dissection?
-
Jun 27, 2026, 18:18Vera Ghali: 2026 ASH–ISTH Recommendations on Pediatric VTE Prevention
-
Jun 27, 2026, 18:17Michiel Coppens: A Hemostasis Laboratory – One of the Cornerstones of Our Hemophilia Mission
-
Jun 27, 2026, 18:16Sthanu Subramanian: Dabigatran and Mechanical Heart Valves
-
Jun 27, 2026, 15:50Muhammet Özbilen: The Skin as an Emerging Regulator of Iron Homeostasis
-
Jun 27, 2026, 15:07Anteneh Berhane: Supporting Healthier Pregnancies Through Early Nutrition
-
Jun 27, 2026, 14:35Mobina Nakhaei: Why Alloantibodies Develop Despite ABO/Rh Matching in Thalassemia
-
Jun 27, 2026, 14:01Abdul Mannan: DOACs in Cancer-Associated VTE – When to Avoid Them, And When LMWH Wins