Enrico Ferro: Thank You Niraj Sharma for Covering Our AFib Ablation Stroke Safety Analysis
Enrico Ferro, Electrophysiology Fellow at Beth Israel Lahey Health, Clinical Investigator at Richard A. and Susan F. Smith Center for Outcomes Research, shared Niraj Sharma‘s post on LinkedIn:
”Thank you Niraj Sharma for covering our comparative safety analysis for stroke during PFA versus radiofrequency ablation of Afib in EP Edge – appreciate your thoughtful and balanced analysis.
As we replicate this study design with a much larger multicenter nationwide cohort, enriched with a higher event rate, we hope to be able to understand the mechanism behind the higher stroke signal observed with the ‘PFA strategy’.
Niraj Sharma, Cardiac Electrophysiologist/Cardiologist at Northside Hospital, shared on LinkedIn:
”Now Live: EP Edge Journal Watch: Issue 22, May 2026
What if the next phase of electrophysiology is not faster procedures, but better definitions of safety, durability, and success?
Issue 22 is now live, and this one sits right at the intersection of PFA maturity, procedural simplification, device strategy, and trial endpoint design.
Inside this issue:
Ferro EHRA 2026 — PFA vs RFA Safety
A provocative real-world neurologic safety signal asks whether we should stop speaking about PFA safety as one global concept.
NAVIGATE-PF Phase 2
A systematic remapping study explores whether second-generation, mapping-integrated pentaspline PFA can deliver durable lesion sets beyond acute isolation.
Long-Term PFA Recurrence After Pentaspline PFA
Early durability is one question. Long-term recurrence is another. This study brings the real-world follow-up lens.
PFA plus LAAO vs RFA plus LAAO
The ‘one-stop’ AF procedure is appealing, but the real question is whether workflow efficiency translates into better structural and clinical outcomes.
PRAETORIAN-DFT
A major S-ICD trial challenges whether routine defibrillation testing is still necessary when implant position is favorable.
CT-Based Leadless Pacemaker Difficulty Score
Can difficult leadless pacemaker implantation be anticipated before the case begins? This paper moves procedural planning upstream.
Memantine for Premature Atrial Contractions
A surprising phase 2 pharmacology trial opens a new discussion about PAC suppression and nontraditional atrial excitability pathways.
Defining Success in AF Ablation
Is the 30-second recurrence endpoint still adequate in the PFA era, or are we measuring modern ablation with an outdated ruler?
No simple conclusions. No overstatement. Just the data, the limitations, and the EP Edge interpretation.
Read the full issue in EP Edge Journal Watch on LinkedIn.
Also available on Substack.
Listen to the companion EP Edge Journal Watch Podcast:
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