Mariam Swidan/LinkedIn
May 22, 2026, 13:31
Mariam Swidan: Why Hemolysis Severity Matters in G6PD Deficiency
Mariam Swidan, Biomedical Science Graduate, Clinical Laboratory Professional, shared a post on LinkedIn:
“Did you know?
In G6PD deficiency, hemolysis can be both intravascular and extravascular, but the mechanism is actually stepwise, not separate.
Oxidative stress first causes hemoglobin denaturation – Heinz body formation.
- In the spleen, macrophages ‘pluck out’ these Heinz bodies – forming bite cells – extravascular hemolysis.
- But if oxidative damage is severe, the RBC membrane becomes too fragile – cells rupture directly in circulation – intravascular hemolysis.
So it’s not two different processes – it’s a spectrum of damage severity.
Clinical insight:
- Milder stress – mostly extravascular
- Severe stress – significant intravascular hemolysis (leads to hemoglobinuria).”
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