Wolfgang Miesbach: Exploring the Role of Micronutrients in Healthy Longevity
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
“New RCT evidence says: possibly yes.
A large-scale randomized controlled trial — the COSMOS study — offers evidence that daily multivitamin–multimineral supplementation may modestly decelerate epigenetic aging in older adults:
Among 958 participants (mean age 70 years), 2 years of daily Centrum Silver — a standard multivitamin — significantly slowed the rise of well-validated epigenetic aging clocks (biological ‘speedometers’ derived from DNA methylation patterns that predict mortality risk).
Importantly, vitamins improved aging biomarkers: telomere length, and markers of cellular senescence, immune activation, and mitochondrial dysfunction.
The benefit was strongest in those with already accelerated biological aging at baseline — suggesting the greatest geroprotective effect in those who may need it most.
Interestingly, cocoa flavanol extract (500 mg/day) showed no significant effect on any of the five epigenetic clocks tested.
However, whether improvements in epigenetic clocks translate into meaningful clinical outcomes still needs to be confirmed in longer follow-up studies.
The authors propose that correcting subclinical micronutrient deficiencies may be the key driver — with likely even greater effects in less well-nourished populations.”
Other posts featuring Wolfgang Miesbach on Hemostasis Today.
-
Aug 21, 2026, 11:02Severe ITP, Critical Bleeding, and the Challenge of Platelet Testing – RPTH Journal
-
Aug 21, 2026, 10:46Arwa Z. Al-Riyami: Looking Ahead to ISBT Muscat 2029
-
Aug 21, 2026, 10:42Janine Mothershed: What Is Romiplostim and How Does It Work in Immune Thrombocytopenia?
-
Aug 21, 2026, 10:33Omar Alkharabsheh: Excited to Build the Future of Hematologic Malignancy Care in Central Florida
-
Aug 21, 2026, 10:23Salvador Payán Pernía: Tailoring Therapy in Sickle Cell Disease – Mitapivat and the Path Toward Personalized Combination Care
-
Aug 21, 2026, 10:10Pete Stibbs: The Evolving Landscape of VTE Management
-
Aug 21, 2026, 09:58Nishant K Mishra։ When Epilepsy Meets Anticoagulation
-
Aug 21, 2026, 09:07Sujal Lohana: Building a Better Blood Donor–Seeker App
-
Aug 21, 2026, 08:55Robert Sidonio: Connecting Experts in Bleeding and Clotting Disorders