Francisco Epelde: Cardiac Lymphatic System as an Active Regulator of Myocardial Homeostasis
Francisco Epelde, Attending Physician, internal Medicine Service at Parc Taulí University Hospital, posted on LinkedIn about his recent article, published in Medical Sciences, adding:
“I am pleased to share my latest article, ‘Cardiac Lymphatic Dysfunction in Heart Failure: A New Paradigm for Congestion, Inflammation, and Therapy,’ published in Medical Sciences.
Heart failure has traditionally been understood through hemodynamic, neurohormonal, and cardiorenal models.
However, these frameworks do not fully explain persistent tissue congestion, unresolved myocardial edema, chronic inflammation, and progressive fibrosis despite optimized therapy.
In this review, I explore the cardiac lymphatic system as an active regulator of myocardial homeostasis.
Rather than being a passive drainage network, cardiac lymphatics may play a central role in linking congestion, inflammation, fibrosis, and ventricular dysfunction.
The article highlights emerging evidence suggesting that lymphatic dysfunction could represent a missing mechanistic bridge in heart failure pathophysiology, while also opening new possibilities for diagnosis, phenotyping, and future therapeutic strategies focused on tissue-level decongestion and lymphatic repair.
Although clinical translation remains investigational, recognizing lymphatic insufficiency as part of the heart failure process may help us rethink how we understand congestion and myocardial remodeling.
I hope this review contributes to the growing discussion around new biological paradigms in heart failure.”
Title: Cardiac Lymphatic Dysfunction in Heart Failure: A New Paradigm for Congestion, Inflammation, and Therapy
Author: Francisco Epelde
Stay updated on all scientific advances with Hemostasis Today.
-
May 26, 2026, 06:39Reza Shojaei: How Neurology is Reshaping the Plasma Market?
-
May 26, 2026, 05:4779th World Health Assembly Approves Global Equity Resolution – EHC
-
May 26, 2026, 03:02Spelile Mutupira: Process of Blood Clotting After Injury
-
May 26, 2026, 03:00Clinton Otwori: Which Blood Product Do Healthcare Workers Most Commonly Misunderstand in Practice?
-
May 26, 2026, 02:58Toriqul Islam: EDTA-Induced Pseudothrombocytopenia
-
May 26, 2026, 02:34James O’Donnell Secures 2 Million Euros for a New Programme on The Irish ABO and Coagulation Study – RCSI
-
May 26, 2026, 02:26Joseph R. Shaw: Join The Annual CanVECTOR National Thrombosis Seminar on Precision in DOAC Reversal
-
May 26, 2026, 01:42Mili Doshi: The Role of Oral Health Teams in Supporting Stroke Rehabilitation and Recovery
-
May 26, 2026, 01:25Mohamed Mamdouh: Advancing Stroke Care Access in Cairo Through the Launch of a New Stroke-Ready Center