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Shamsunisha Yusuff: Iron Down, Platelets Up in a Young CBC ?
Shamsunisha Yusuff/LinkedIn
Jun 8, 2026, 03:05

Shamsunisha Yusuff: Iron Down, Platelets Up in a Young CBC ?

Shamsunisha Yusuff, Resident Doctor at Tamil Nadu Dr. M.G.R. Medical University (TNMGRMU), shared a post on LinkedIn:

“Iron down, platelets up in a young CBC ? – NOT a bone marrow disorder alreadyy!

Hb: 8 g/dL
MCV: 68 fL
Ferritin: Low
Platelets: 550,000/μL [ Normal: ~150,000–450,000/μL ]

Ft. A CBC that screams Microcytic anemia but also whispers Iron-Deficiency Anemia, yet hints a concern about the platelet count.

Welcome to learning a new term, today : ‘ Reactive Thrombosis ‘

Why Does It Happen?

A 3-way door :

1. Bone marrow stimulation :

  • Iron deficiency triggers increased hematopoietic activity in the bone marrow.
  • The same marrow that makes RBCs also makes platelets, so platelet production may increase.

2. Shared growth factors

  • Cytokines and growth factors involved in blood cell production may indirectly stimulate megakaryocytes (platelet-producing cells).

3. Compensatory response

  • Chronic blood loss (such as heavy menstrual bleeding) can lead to both iron deficiency and a reactive increase in platelets.

next time u see higher platelets in a young CBC , calm down Zendaya, take a quick check at anemia , revise today!”

Shamsunisha Yusuff

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