Mobina Nakhaei: Why Alloantibodies Develop Despite ABO/Rh Matching in Thalassemia
Mobina Nakhaei, Researcher in Hematology and Transfusion Medicine and Member of the Educational Development Center at Tarbiat Modares University, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Annals of Hematology, adding:
“Why Do Thalassemia Patients Still Develop Alloantibodies Despite ABO/Rh Matching?
A question we addressed in our study on transfusion‑dependent β‑thalassemia patients in Eastern Iran.
Our findings, published in Annals of Hematology (Springer), highlight the ongoing challenge of red blood cell alloimmunization – even with standard ABO and Rh matching.
What we found:
- 74 patients (50% male, 50% female) from South Khorasan
- Alloimmunization prevalence: 9.5%
- 16 alloantibodies identified
- Most common: anti‑K (43.75%) and anti‑E (43.75%)
- Followed by anti‑C (12.5%)
- Blood group O was the most frequent phenotype (39.2%)
- Rh antigens c and e: present in 94.6%
- No significant association with age, sex, blood group, or splenectomy
The takeaway:
To improve transfusion safety, we need to go beyond ABO/Rh – extended matching for Kell and Rh systems, combined with regular antibody screening, is essential in high‑risk populations.
Grateful to my supervisor Fatemeh Mezginejad and my colleague for their collaboration on this work.”
Title: Red blood cell alloimmunization in transfusion-dependent β-thalassemia major patients in Eastern Iran
Authors: Mobina Nakhaei Shamahmood, Mohammad Reza Meghdadi, Maziar Nasiri, Mohammad Javad Yousefi, Fatemeh Mezginejad
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