Ramesh Chennupat: Anemia is Associated with Increased REV Release in Stable Coronary Artery Disease
Ramesh Chennupat, Group Leader at Cardiology Department at University Hospital Düsseldorf, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Molecular and Cellular Cardiology, adding:
“I am pleased to share our latest work from my research group:
‘Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction.’
Accepeted in the Journal of Molecular and Cellular Cardiology. JMCC Journals
Our study demonstrates that anemia in patients with stable coronary artery disease is associated with increased release of red blood cell–derived extracellular vesicles (REVs).
These anemic REVs show enhanced nitric oxide consumption and carry oxidative sterss promoting myeloperoxidase, leading to endothelial dysfunction both in vitro and in vivo.
Targeting MPO-driven oxidative stress within REVs was able to reverse these detrimental effects, highlighting a potential therapeutic avenue.
Overall, our findings reveal a novel mechanistic link between anemia, red blood cell vesiculation, and vascular dysfunction in coronary artery disease.”
Title: Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction
Authors: Isabella Solga, Leon Götzmann, Vithya Yogathasan, Patricia Wischmann, Tin Yau Pang, Patricia Kleimann, Sebastian Temme, Lina Hofer, Anja Stefanski, Alexander Lang, Georg Nickenig, Christian Jung, Norbert Gerdes, Mohammed Rabiul Hosen, Malte Kelm, Ramesh Chennupati
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