Mihaela Cordeanu: Can D-dimer Help Diagnose Splanchnic Vein Thrombosis?
Mihaela Cordeanu, Associate Professor and Hospital Practitioner in Vascular Medicine at Strasbourg University Hospital, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in JVS-Vascular Insights, adding:
“Can D-dimer help diagnose Splanchnic Vein Thrombosis?
Pleased to share our systematic review published in JVS-Vascular Insights, co-authored with Simon Soudet and Prof Dominique Stephan.
We analyzed 25 studies (9,052 patients) evaluating D-dimer diagnostic accuracy for SVT.
Key findings:
- Highly variable performance (sensitivity 54–95%, specificity 33–96%)
- Accuracy declines with worsening hepatic function, a clinical paradox, as advanced cirrhotic patients carry the highest PVT risk yet show the poorest D-dimer performance
- High negative predictive value only in selected low-risk populations (Child-Pugh A)
- Multimarker models (D-dimer and P-selectin or von Willebrand factor) outperform D-dimer alone but remain research tools
Bottom line: D-dimer cannot serve as a universal standalone rule-out test for SVT. Imaging remains the diagnostic cornerstone, consistent with major international guidelines.”
Title: D-dimer diagnostic performance for splanchnic vein thrombosis: A systematic review
Authors: Elena-Mihaela Cordeanu, Simon Soudet, Dominique Stephan
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 16, 2026, 13:53Honey Blankenship: United by a Shared Commitment to the Bleeding Disorders Community
-
Aug 16, 2026, 13:46Sagar Bejalwar: A Rare Bleeding Disorder and the Importance of Specialized Care
-
Aug 16, 2026, 13:39Sharun Khan: Advancing Regenerative Medicine Through Veterinary Translational Science
-
Aug 16, 2026, 13:21Francois Roubille: New ESC Consensus on Inflammation in Coronary Syndromes
-
Aug 16, 2026, 13:05Neil Morgan: Submit Your Abstract for BSHT 2027
-
Aug 16, 2026, 12:50Heba Youssef: Can Cefoperazone Cause Coagulopathy?
-
Aug 16, 2026, 12:35Mohammad Alkhalil: Stroke Remains a Dreaded Complication in TAVI
-
Aug 16, 2026, 12:16Jeff Schaffnit: The Power of Community in Rare Blood Disorders
-
Aug 16, 2026, 12:03Fawaz AlOtaibi: Can AI Replace Contrast CTA for Vascular Screening?