Mihaela Cordeanu: Can D-dimer Help Diagnose Splanchnic Vein Thrombosis?
Mihaela Cordeanu, Associate Professor and Hospital Practitioner in Vascular Medicine at Strasbourg University Hospital, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in JVS-Vascular Insights, adding:
“Can D-dimer help diagnose Splanchnic Vein Thrombosis?
Pleased to share our systematic review published in JVS-Vascular Insights, co-authored with Simon Soudet and Prof Dominique Stephan.
We analyzed 25 studies (9,052 patients) evaluating D-dimer diagnostic accuracy for SVT.
Key findings:
- Highly variable performance (sensitivity 54–95%, specificity 33–96%)
- Accuracy declines with worsening hepatic function, a clinical paradox, as advanced cirrhotic patients carry the highest PVT risk yet show the poorest D-dimer performance
- High negative predictive value only in selected low-risk populations (Child-Pugh A)
- Multimarker models (D-dimer and P-selectin or von Willebrand factor) outperform D-dimer alone but remain research tools
Bottom line: D-dimer cannot serve as a universal standalone rule-out test for SVT. Imaging remains the diagnostic cornerstone, consistent with major international guidelines.”
Title: D-dimer diagnostic performance for splanchnic vein thrombosis: A systematic review
Authors: Elena-Mihaela Cordeanu, Simon Soudet, Dominique Stephan
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 2, 2026, 13:50Arnav Garcha: New Insights Into Platelet Transport in Arterial Flow
-
Oct 2, 2026, 13:49Alessandro Lucchesi: RiseMPN 2026 – Shaping the Future of MPN Treatment
-
Oct 2, 2026, 13:43Ronald Mahomane: Bangladesh Moves Toward Sustainable Hemophilia Treatment Access
-
Oct 2, 2026, 13:38Sathya-Prasad Burjonrappa: Pediatric Trauma and Deep Venous Thrombosis
-
Oct 2, 2026, 12:50Ravi C Dara: ADHAR 2026 – Red Cell Exchange in Sickle Cell Disease
-
Oct 2, 2026, 12:37David McIntosh: WeDonate Partners with Dr. Martens to Reward UK Blood Donors
-
Oct 2, 2026, 12:31Ahmed Salah El-Deen: HELLP Syndrome – An Obstetric Emergency
-
Oct 2, 2026, 12:28Swapnil Hiremath: Transitioning from Idiopathic Thrombocytopenia to Antiphospholipid Syndrome in Recurrent Severe Preeclampsia
-
Oct 2, 2026, 12:08Austin Camp: Learn How to Treat HIT from an ICU Pharmacist in 60 Seconds!