Quintijn Bonnez: How ADAMTS13 Conformation May Predict Early Relapse and Guide Pre-Emptive Therapy
Quintijn Bonnez, Early-Career Board Member at Belgian Society on Thrombosis and Haemostasis, shared a post on LinkedIn about a recent article he and Karen Vanhoorelbeke co-authored, published in Belgian Journal of Hematology, adding:
“Have you already received your copy ?
Excited to see our Hematology review covered on the latest edition of the Belgian Journal of Hematology.
In this review, the evidence for open ADAMTS13 as a highly specific biomarker for both acute and subclinical iTTP was summarized. Beyond its diagnostic value, we highlighted how ADAMTS13 conformation may contribute to early relapse risk prediction and help guide pre-emptive therapeutic interventions.
Key messages for clinical practice:
- ADAMTS13 conformation adds diagnostic value beyond testing Enzyme activity.
- Distinct, open ADAMTS13 is characteristic for iTTP.
- Closed ADAMTS13 is preserved in healthy individuals and non-iTTP clinical conditions.
This exciting work continues to bridge fundamental protein Biology with clinical decision-making, bringing us one step closer to improved diagnosis and patient monitoring.”
Title: Distinct open ADAMTS13 for diagnosing and monitoring acute and subclinical immune-mediated thrombotic thrombocytopenic purpura
Authors: Quintijn Bonnez, Karen Vanhoorelbeke
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