Evangelia Petsalaki: New Systems Biology Approach Identifies Biomarkers in Thrombotic APS
Evangelia Petsalaki, Director of Oncology Data Science Innovation at GSK and Visiting Group Leader at EMBL-EBI, shared on LinkedIn about a recent article she and her colleagues co-authored, published in medRxiv, adding:
”We’re pleased to share our latest preprint on thrombotic primary antiphospholipid syndrome (APS).
In this study, we integrated plasma proteomics, whole-blood transcriptomics, machine learning and network-based analysis to investigate the molecular programmes associated with high-risk disease.
Across multiple complementary analyses, we found evidence for a complement- and interferon-associated thromboinflammatory programme linked to increasing antiphospholipid antibody burden and recurrent thrombosis. Integrating the data using multi-omics factor analysis and network propagation also connected circulating protein signatures to intracellular signalling pathways, providing a systems-level view of disease biology.
Among the findings, Complement Factor D (CFD) emerged as a candidate biomarker associated with recurrent thrombosis, although this will require validation in independent cohorts.
This work was a fantastic collaboration between colleagues at EMBL-EBI, the National and Kapodistrian University of Athens, and the Biomedical Sciences Research Center ‘Alexander Fleming’.
Many thanks to everyone involved, especially Srijith Sasikumar and Maria Tektonidou as well as our coauthors Michail Baltsiotis, Kleio-Maria Verrou, Georgia Rouni, Martina Samiotaki, Petros Sfikakis and the rest of the team.”
Title: Multi-omics and network propagation reveal latent innate immune programmes stratifying high-risk thrombotic primary antiphospholipid syndrome
Authors: Srijith Sasikumar, Michail Baltsiotis, Kleio-Maria Verrou, Georgia Rouni, Petros P. Sfikakis, Martina Samiotaki, Evangelia Petsalaki, Maria G. Tektonidou
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 10, 2026, 20:47New Machine Learning Models Improve Prediction of Thrombosis and Bleeding in Cancer – JTH
-
Jul 10, 2026, 20:29Wolfgang Miesbach: Celebrating Pantep Angchaisuksiri’s Transformative Leadership of the ISTH
-
Jul 10, 2026, 20:17Amy Pantaleo: How Staffing Shortages Are Changing Hemostasis Laboratories
-
Jul 10, 2026, 20:15Gene Nudelman: Early Hemorrhage Control Improves Patient Outcomes
-
Jul 10, 2026, 20:15Lee G.: Can We Transform Dengue Patient Management with Better Coagulation Assessment?
-
Jul 10, 2026, 20:13Shahin Alam: Is Your Coagulant Limiting Your Water Treatment Performance?
-
Jul 10, 2026, 20:12Ali Bozorgi: Our Meta-Analysis on Oral Anticoagulation After AF Ablation Featured in EP Europace
-
Jul 10, 2026, 15:34Joy Celebre: A New Opportunity in Hemostasis Leadership
-
Jul 10, 2026, 15:11Thirunavukkarasu Angappan: The Geopolitics of Plasma Supply and Self-Sufficiency