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Subodh Grewal: RBC and Platelet Histogram Interpretation
Subodh Grewal/LinkedIn
Jul 24, 2026, 16:52

Subodh Grewal: RBC and Platelet Histogram Interpretation

Subodh Grewal, Technical Support Engineer at Promea Therapeutics, shared a post on LinkedIn:

“RBC and Platelet Histogram Interpretation | 5-Part Hematology Analyzer

Histograms provide a graphical representation of cell volume distribution and can help identify abnormal patterns alongside numerical CBC results.

RBC Histogram

  • Left shift: Predominance of smaller RBCs
  • Right shift: Predominance of larger RBCs
  • Broad distribution: Increased variation in RBC size (RDW)
  • Bimodal pattern: Two distinct RBC populations may be present

Platelet Histogram

Distribution pattern reflects platelet volume and size variation

Right-sided extension may indicate larger/giant platelets

Abnormal curves can also result from platelet clumps, cell fragments, microcytic RBC interference, or sample-related factors

From a technical perspective, an abnormal histogram should not immediately be considered a patient abnormality.

Always evaluate sample quality, analyzer flags, background, reagents, possible clogging, and instrument performance where applicable.

Key Approach:

Check Numeric Results, then Review Flags, Analyze the Histogram, Rule Out Sample or Technical Interference, and Correlate Clinically and Review

Peripheral Smear when indicated

This is Page 2 of my Hematology Result Interpretation Series.”Subodh Grewal: RBC and Platelet Histogram Interpretation

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