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Umberto Pensato: New BMJ Review on Breakthrough Stroke in Patients Receiving DOACs Is Now Live
Umberto Pensato/LinkedIn; Ronda Lun/photo:ohri.ca
Jul 28, 2026, 02:38

Umberto Pensato: New BMJ Review on Breakthrough Stroke in Patients Receiving DOACs Is Now Live

Umberto Pensato, Assistant Professor of Neurology at the Humanitas University, Research Collaborator at the University of Calgary, shared on LinkedIn about a recent article he and his colleagues co-authored, published in BMJ, adding:

”Out now on the BMJ, our comprehensive review on breakthrough stroke (stroke despite DOAC) which accounts for nearly one in seven ischemic stroke in daily practice (yet has been largely neglected until recently).

Here we review the epidemiology, mechanisms, a framework for classification, and mangement of this condition.

Notably, we also propose a systematic, stepwise algorithm for investigation, along with standardized criteria to select patients for future randomized clinical trials (AF-BREACH criteria)

Kudos to Ronda Lun for leading this review over the last two years and pulling together a terrific international, multidisciplinary team covering neurology, cardiology, and hematology.”

Title: Investigation and management of breakthrough ischemic stroke in anticoagulated patients with atrial fibrillation

Authors: Ronda Lun, Umberto Pensato, Joseph R. Shaw, Carlo A. Pivato, Luciano A. Sposato, Thalia S. Field, Andrew M. Demchuk

Umberto Pensato: New BMJ Review on Breakthrough Stroke in Patients Receiving DOACs Is Now Live

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AF AF-BREACH Andrew M. Demchuk Atrial Fibrillation BMJ Carlo A. Pivato DOAC Health Hematology Hemostasis Hemostasis News Hemostasis Today Joseph R. Shaw Luciano A. Sposato Medicine Ronda Lun stroke Thalia S. Field thrombosis Umberto Pensato
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