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Wendy Stam: Revealing How Anti-HPA-1a Antibodies Lock Integrins in an Inactive State
Wendy Stam/ LinkedIn
Jul 30, 2026, 10:14

Wendy Stam: Revealing How Anti-HPA-1a Antibodies Lock Integrins in an Inactive State

Wendy Stam, PHD Candidate at Leiden University, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:

“I am excited and grateful to share that not one, but two papers, showcasing my PhD work, were published recently!

We have shown that binding of anti-HPA-1a antibodies to both αvβ3 and αIIbβ3 integrins, inhibit integrin function by retaining the integrin in the bent conformation, impairing integrin activation and platelet aggregation. (Blood, PMID: 41980042)

On top of that, in close collaboration with Cryo-EM experts, we were able to visualize the binding of an anti-HPA-1a antibody in complex with the αIIbβ3 integrin, explaining this inactive integrin lock mechanism. (Science Advances, PMID: 42467762)

A big thank you to the people who participated and made this a success; Femke van der Meer, Jeremy Broekhuis, Janita Oosterhoff, Marcos Gragera Cabezudo, Gestur Vidarsson, Ellen van der Schoot, José de Pereda and Coert Margadant.”

Title: Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity

Authors: Wendy Stam, Jeremy D. Broekhuis, Femke W. T. van der Meer, Raoul P. Pirée, Janita J. Oosterhoff, José María de Pereda, Ellen van der Schoot, Gestur Vidarsson, Coert Margadant

Wendy Stam: Revealing How Anti-HPA-1a Antibodies Lock Integrins in an Inactive State

Title: High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

Authors: José M. de Pereda, Wendy Stam, Marcos Gragera, Femke van der Meer, Francisco J. Chichón, Eleftherios Zarkadas, Ellen van der Schoot, Gestur Vidarsson, Junichi Takagi, Coert Margadant

Wendy Stam: Revealing How Anti-HPA-1a Antibodies Lock Integrins in an Inactive State

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Blood Coert Margadant Eleftherios Zarkadas Ellen van der Schoot Femke van der Meer Femke W.T. van der Meer Francisco J. Chichón Gestur Vidarsson Health Hematology Hemostasis Hemostasis News Hemostasis Today Janita J. Oosterhoff Jeremy D. Broekhuis José M. de Pereda Jose Maria de Pereda Junichi Takagi Marcos Gragera Medicine Raoul P. Pirée Science Advances Wendy Stam
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