Nadine Schwarz: How Genetic Variation Shapes Protein C Pathway Function
Nadine Schwarz, Research Associate at Institute of Experimental Hematology and Transfusion Medicine in University Hospital Bonn, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood Advances, adding:
“Excited to share our latest publication in Blood Advances!
We investigated how common genetic variants in THBD and PROCR influence the anticoagulant response of the protein C pathway using both in vivo and ex vivo experimental models.
By combining controlled coagulation activation in human participants with endothelial cell-based functional assays, we were able to dissect the distinct effects of these variants on protein C pathway function.
I am grateful to all my colleagues and co-authors who contributed to this study.”
Title: In vivo and ex vivo impact of THBD and PROCR polymorphisms on the anticoagulant response of the protein C pathway
Authors: Sara Reda, Nadine Schwarz, Sebastian Eckert, Jens Müller, Johannes Oldenburg, Bernd Pötzsch, Behnaz Pezeshkpoor, Heiko Rühl
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