Yiliang Chen: PIM1 Identified as a Driver of Macrophage Foam Cell Formation in Atherosclerosis
Yiliang Chen, Assistant Professor at Medical College of Wisconsin, Assistant Investigator at Versiti Blood Research Institute, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Arteriosclerosis, Thrombosis, and Vascular Biology, adding:
“I’m delighted to share that our latest research has been published in Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB): Macrophage PIM1 Drives Atherosclerosis by Enhancing Foam Cell Formation Via CD36.
In this study, we demonstrate that PIM1 kinase promotes macrophage foam cell formation by enhancing CD36-dependent oxidized LDL uptake, uncovering a new mechanism by which PIM1 contributes to the development of atherosclerosis.
These findings identify PIM1 as an important regulator of macrophage lipid metabolism and provide new insight into the molecular pathways that drive cardiovascular disease.
This project represents years of dedicated work by an outstanding team of students, postdoctoral fellows, collaborators, and mentors.
I’m deeply grateful for everyone’s perseverance, creativity, and commitment throughout this journey.
Congratulations and thank you to all of my co-authors Mirza Ahmar Beg, QUOC QUANG LUU, Silverstein Roy and collaborators Gang Xin.
I look forward to seeing where this work leads next.”
Title: Macrophage PIM1 Drives Atherosclerosis by Enhancing Foam Cell Formation Via CD36
Authors: Mirza Ahmar Beg,, Quoc Quang Luu, Vaya Chen, Yaxin Wang, Gang Xin, Weiguo Cui, Roy L. Silverstein, Yiliang Chen
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 7, 2026, 14:49Ana Sachetto: Investigating TF-Positive Extracellular Vesicles and DIC in Sepsis
-
Aug 7, 2026, 14:43How the WFH Shared Decision-Making Tool Empowers Bleeding Disorder Patients – WFH
-
Aug 7, 2026, 14:37Maria Roussakis: Are You Prescribing Blood Transfusions for Adult Thalassemia?
-
Aug 7, 2026, 14:30Hakkı Yılmaz: Precision Medicine Gains Momentum in ANCA-Associated Vasculitis
-
Aug 7, 2026, 13:30Nicole McWilliams: Victorian Melodrama Meets Vascular Medicine
-
Aug 7, 2026, 11:49Julia Korobkin: How Scientific Networking Solved Real Lab Challenges
-
Aug 7, 2026, 08:13Felicia Ikolo: Could Earlier Oxygen Therapy Change the Course of Sickle Cell Crisis?
-
Aug 7, 2026, 07:59Dina Vara: Advancing Lyophilized Platelets for Transfusion Medicine
-
Aug 7, 2026, 07:43Martin Tøffner Pedersen: Reducing False-Negative Results in Transfusion Testing