Jean Connors: Can Prothrombin Levels Improve Antiphospholipid Syndrome Risk Assessment?
Jean Connors, Chief of Cancer Hematology at Dana-Farber Cancer Institute, shared Journal of Thrombosis and Haemostasis (JTH)’s post on LinkedIn, adding:
“We need a functional assay to assay prothrombotic potential of aPL–this is getting closer to identifying the impact of these antibodies.”
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Maria Grazia Cattini et al., adding:
“Plasma prothrombin antigenic levels across thrombotic and hemorrhagic phenotypes in triple-positive antiphospholipid patients with anti-prothrombin antibodies
In antiphospholipid patients carrying anti-prothrombin antibodies, plasma prothrombin levels appear to set the balance between clotting and bleeding.
As antigenic prothrombin fell, the phenotype shifted from thrombotic toward hemorrhagic along a continuum.
Measuring prothrombin antigen in these high-risk patients could sharpen risk stratification and help guide whether to lean toward anticoagulation or caution.”
Title: Plasma prothrombin antigenic levels across thrombotic and hemorrhagic phenotypes in triple-positive antiphospholipid patients with antiprothrombin antibodies
Authors: Maria Grazia Cattini, Elena Pontara, Elisa Bison, Marta Tonello, Alida Linda Patrizia Caforio, Nicola Pozzi, Vittorio Pengo
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