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Suspicion-Based Screening for Occult Malignancy in Lower Extremity Venous Thrombosis – JTH
Aug 17, 2026, 16:56

Suspicion-Based Screening for Occult Malignancy in Lower Extremity Venous Thrombosis – JTH

Journal of Thrombosis and Haemostasis (JTH), shared a post on LinkedIn about a recent article by Yael Appelboom, adding:

“Suspicion-based screening for occult malignancy in lower extremity venous thrombosis: a real-world cohort study

Whether to hunt for hidden cancer after deep vein thrombosis stays contested.

Across 1,285 patients followed for a median of five years, first-year malignancy incidence was 6.2percent after DVT versus about 2percent in superficial thrombosis and controls.

A suspicion-based approach, testing further only when clinical clues appeared, missed few cancers and reached a negative predictive value of 98.2percent in DVT.”

Title: Suspicion-based screening for occult malignancy in lower-extremity venous thrombosis: a real-world cohort study

Authors: Yael Appelboom, Inge H.Y. Luu, Aukje Swillens, Eveline Bos, Kon-Siong G. Jie, Roel van Kampen, Math P.G. Leers, Guy J.M. Mostard, Daan J.L. van Twist

Suspicion-Based Screening for Occult Malignancy in Lower Extremity Venous Thrombosis - JTH

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Aukje Swillens Daan J. L. van Twist Eveline Bos Guy J.M. Mostard Health Hematology Hemostasis Hemostasis News Hemostasis Today Inge H.Y. Luu Journal of Thrombosis and Haemostasis (JTH) Kon-Siong G. Jie Math P.G. Leers Medicine Roel van Kampen Yael Appelboom
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