Agnese Lucchetti: High Shear Drives Acute Carotid Stent Thrombosis in Tandem Lesions
Agnese Lucchetti, Postdoctoral Researcher at RWTH Aachen University, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Journal of the American Heart Association, adding:
”Have a look at the new paper of Axelle Y. Kern and co-authors, ‘High-Shear Environment Promotes Acute Carotid Stent Thrombosis in Patients With Tandem Lesions,’ published in the Journal of the American Heart Association.
In this study:
- An original macrofluidic model was used to characterize in depth the thrombogenicity of clinically used carotid stents.
- This experimental approach was combined with computational fluid dynamics analysis to pinpoint the rheological conditions that trigger thrombosis in a stent placed at the carotid bifurcation.
- These findings were confirmed by a retrospective clinical study in patients with tandem lesions, which showed massive thrombus formation occurring at the bifurcation.
- Finally, an alternative stent design — developed at the ITA Institute of Textile Technology at RWTH Aachen Universityis presented as a way to limit the formation of large thrombi in this region.”
Title: High‐Shear Environment Promotes Acute Carotid Stent Thrombosis in Patients With Tandem Lesions
Authors: Axelle Y. Kern, Yevgeniy Kreinin, Lise Charle, Camille Robert, Mark Epshtein, Agnese Lucchetti, Caroline Emonts, Tim Bolle, Thomas Gries, Nabil Chakfé, Raoul Pop, Netanel Korin, Pierre H. Mangin
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