Nishant K Mishra։ When Epilepsy Meets Anticoagulation
Nishant K Mishra, Stroke Director at U.S. Department of Veterans Affairs, shared on LinkedIn about a recent article he and his colleagues co-authored, published in JAMA Neurology, adding:
”Pleased to share our new study in JAMA Neurology: ‘Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy.’
In this international real-world study of adults with epilepsy receiving direct oral anticoagulants (DOACs), antiseizure medication choice was associated with meaningful differences in thromboembolic, bleeding, and mortality outcomes.
Notably, compared with lamotrigine/lacosamide, levetiracetam was associated with a higher thromboembolic risk, as were strong enzyme-inducing antiseizure medications.
These findings raise an important and very practical question: When treating epilepsy in a patient who requires anticoagulation, could antiseizure medication selection itself be a modifiable contributor to vascular outcomes?
Congratulations to Kai Michael Schubert, Marian Galovic, and the entire international collaborative team. Grateful to have contributed to this work.”
Title: Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy
Authors: Kai Michael Schubert, Carolina Ferreira-Atuesta, Arunachalam Soma, Johan Zelano, David J Seiffge, Francesco Brigo, Eugen Trinka, Nishant K Mishra, Emilio Russo, Gregory Y H Lip, Gashirai K Mbizvo, Marian Galovic
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 21, 2026, 12:08Amy Allen Whitfield: Helping to Proceed Bleeding Disorders Care
-
Aug 21, 2026, 11:53Jan Terje Andersen: Harnessing Placental Biology for Therapeutic Engineering
-
Aug 21, 2026, 11:02Severe ITP, Critical Bleeding, and the Challenge of Platelet Testing – RPTH Journal
-
Aug 21, 2026, 10:46Arwa Z. Al-Riyami: Looking Ahead to ISBT Muscat 2029
-
Aug 21, 2026, 10:42Janine Mothershed: What Is Romiplostim and How Does It Work in Immune Thrombocytopenia?
-
Aug 21, 2026, 10:33Omar Alkharabsheh: Excited to Build the Future of Hematologic Malignancy Care in Central Florida
-
Aug 21, 2026, 10:23Salvador Payán Pernía: Tailoring Therapy in Sickle Cell Disease – Mitapivat and the Path Toward Personalized Combination Care
-
Aug 21, 2026, 10:10Pete Stibbs: The Evolving Landscape of VTE Management
-
Aug 21, 2026, 09:07Sujal Lohana: Building a Better Blood Donor–Seeker App