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Heghine Khachatryan: Prepartum Acquired Hemophilia A and the Challenge of Maternal and Neonatal Bleeding
Heghine Khachatryan/LinkedIn
Aug 24, 2026, 13:49

Heghine Khachatryan: Prepartum Acquired Hemophilia A and the Challenge of Maternal and Neonatal Bleeding

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared Journal of Thrombosis and Haemostasis‘s post on LinkedIn about a recent article by Audrey Hochart et al., adding:

“A highly relevant and timely publication addressing one of the most complex and underrecognized challenges in haemostasis: prepartum acquired haemophilia A.

Although rare, this potentially life-threatening condition may progress rapidly and poses serious risks to both mother and child. Its clinical relevance lies in the need for increased awareness, early recognition of unexpected bleeding and isolated APTT prolongation, prompt confirmation of factor VIII deficiency and inhibitor presence, and immediate initiation of individualized haemostatic and immunosuppressive treatment.

Successful management requires close multidisciplinary collaboration among haematologists, obstetricians, anaesthesiologists, neonatologists, and laboratory specialists. Sharing such clinical experience is essential for improving diagnostic vigilance, reducing delays in treatment, and achieving safer maternal and neonatal outcomes.

At Hemostasis Today, we consider raising awareness of rare bleeding disorders in women and pregnancy an important priority and strongly support the exchange of evidence-based clinical experience.”

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Audrey Hochart et al., adding:

“Prepartum acquired hemophilia A: managing a double challenge for mother and child

Acquired hemophilia A during pregnancy is very rare and threatens both mother and fetus, since factor VIII inhibitors can cross the placenta. Across four antenatally diagnosed cases, all mothers received corticosteroids with individualized peripartum bypassing agents. Inhibitor transfer caused transient low FVIII in three neonates with only one mild bleed, and all infants remitted within weeks. Some mothers needed rituximab.”

Title: Prepartum acquired hemophilia A: managing a double challenge for mother and child

Authors: Audrey Hochart, Bénédicte Wibaut, Louis Terriou, Benoit Guillet, Nicolas Belhomme, Nicolas Schleinitz, Mélanie Y Daniel, Sophie Susen, Annabelle Dupont, Sophie Bayart, Céline Falaise, Audrey F Petit

Heghine Khachatryan: Prepartum Acquired Hemophilia A and the Challenge of Maternal and Neonatal Bleeding

Other posts featuring Heghine Khachatryan and Journal of Thrombosis and Haemostasis on Hemostasis Today.

Acquired Hemophilia A Annabelle Dupont Audrey F Petit Audrey Hochart Bénédicte Wibaut Benoît Guillet Céline Falaise Clinical Awareness Factor VIII inhibitor Hematology Hemostasis Hemostasis Today Louis Terriou Maternal Health medical education Melanie Y Daniel Multidisciplinary Care Nicolas Belhomme Nicolas Schleinitz Pregnancy And Hemostasis Rare Bleeding Disorders Sophie Bayart Sophie Susen Womens Bleeding Disorders
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