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Atoosa Salimi: The Role of Platelet-Derived Serotonin in Severe COVID-19
Atoosa Salimi/LinkedIn
Sep 8, 2026, 08:23

Atoosa Salimi: The Role of Platelet-Derived Serotonin in Severe COVID-19

Atoosa Salimi, Senior General Practitioner, shared a post on LinkedIn about a recent article by Davide Marotta et al, published in Science Immunology, adding:

“The factors that drive age-related susceptibility to severe COVID-19 and related disorders like COVID-19–associated coagulopathy (CAC) are not completely understood.

Marotta et al. report that platelets from middle-aged mice (as well as from aged human healthy donors) release higher levels of serotonin, which promotes platelet aggregation and fibrin deposition in the lungs.

Inhibition of serotonin uptake or blockade of downstream serotonin signaling in a model of COVID-19 ameliorates platelet hyperactivation and protects middle-aged mice from severe disease.

This effect is dependent on fibrin formation but independent of viral replication and immune cell infiltration.

The serotonin-fibrin axis therefore has the potential to serve as a therapeutic target for certain at-risk populations afflicted with COVID-19–related diseases. —Seth Thomas Scanlon.”

Title: Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection

Authors: Davide Marotta, Chiara Perucchini, Marta Grillo, Valeria Fumagalli, Pietro Di Lucia, Jordan Rixon, Micol Ravà, Leonardo Giustini, Chiara Malpighi, Giulia D’Uonnolo, Mariangela Scavone, Violette Mouro, Caitlin Abbott, Natalia Stachura-Chyla, Francesco Andreata, Erica Scalambrino, Marigrazia Clerici, Lorena Donnici, Marika Longo Minnolo, Donato Inverso, Raffaele De Francesco, Mauro Gaya, Zaverio M. Ruggeri, Armando Tripodi, Gian Marco Podda, Luca G. Guidotti, Matteo Iannacone, Marco De Giovanni

Atoosa Salimi: The Role of Platelet-Derived Serotonin in Severe COVID-19

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Age-Related Disease Armando Tripodi Atoosa Salimi Caitlin Abbott Chiara Malpighi Chiara Perucchini Clinical Research Coagulopathy Covid-19 COVID-19-Associated Coagulopathy Davide Marotta Donato Inverso Erica Scalambrino Fibrin Francesco Andreata Gian Marco Podda Giulia D’Uonnolo Hematology Hemostasis News Hemostasis Today Immunology Jordan Rixon Leonardo Giustini Lorena Donnici Luca G. Guidotti lung pathology Marco De Giovanni Mariangela Scavone Marigrazia Clerici Marika Longo Minnolo Marta Grillo Matteo Iannacone Mauro Gaya Medical Research Micol Ravà Natalia Stachura-Chyla Pietro Di Lucia platelets Pulmonology Raffaele De Francesco SARS-CoV-2 Science Immunology serotonin thrombosis Valeria Fumagalli Violette Mouro Virology Zaverio M. Ruggeri
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