Atoosa Salimi: The Role of Platelet-Derived Serotonin in Severe COVID-19
Atoosa Salimi, Senior General Practitioner, shared a post on LinkedIn about a recent article by Davide Marotta et al, published in Science Immunology, adding:
“The factors that drive age-related susceptibility to severe COVID-19 and related disorders like COVID-19–associated coagulopathy (CAC) are not completely understood.
Marotta et al. report that platelets from middle-aged mice (as well as from aged human healthy donors) release higher levels of serotonin, which promotes platelet aggregation and fibrin deposition in the lungs.
Inhibition of serotonin uptake or blockade of downstream serotonin signaling in a model of COVID-19 ameliorates platelet hyperactivation and protects middle-aged mice from severe disease.
This effect is dependent on fibrin formation but independent of viral replication and immune cell infiltration.
The serotonin-fibrin axis therefore has the potential to serve as a therapeutic target for certain at-risk populations afflicted with COVID-19–related diseases. —Seth Thomas Scanlon.”
Title: Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
Authors: Davide Marotta, Chiara Perucchini, Marta Grillo, Valeria Fumagalli, Pietro Di Lucia, Jordan Rixon, Micol Ravà, Leonardo Giustini, Chiara Malpighi, Giulia D’Uonnolo, Mariangela Scavone, Violette Mouro, Caitlin Abbott, Natalia Stachura-Chyla, Francesco Andreata, Erica Scalambrino, Marigrazia Clerici, Lorena Donnici, Marika Longo Minnolo, Donato Inverso, Raffaele De Francesco, Mauro Gaya, Zaverio M. Ruggeri, Armando Tripodi, Gian Marco Podda, Luca G. Guidotti, Matteo Iannacone, Marco De Giovanni
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