Joseph Aslan։ Targeting Mitochondrial Permeability Transition To Reduce Platelet Thrombogenicity
Joseph Aslan, Associate Professor at Oregon Health and Science University, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Blood, adding:
”Happy to share our paper, now online as a Blood First Edition article, led by graduate student Yiheng Zhang.
We characterized small molecule inhibitors of the mitochondrial permeability transition pore (mPTP) that selectively suppress platelet procoagulant activity and limit thrombosis while preserving key platelet functions, including aggregation and secretion.
Grateful to Yiheng, Jordan, Vrishank, Moua Yang, Owen McCarty, Michael Cohen and all our Oregon Health and Science University and Oregon State University and other collaborators for their contributions to this work.
Read the paper ‘Inhibition of mitochondrial permeability transition selectively suppresses thrombogenic platelet procoagulant activity’ ”
Title: Inhibition of mitochondrial permeability transition selectively suppresses thrombogenic platelet procoagulant activity
Authors: Yiheng Zhang, Jordan Sandler, Osamede Clinton Owegie, Xu Zhang, Vrishank Shivaprakash, Jack Kurth, Yong Sun, Mayu Morita, Raquel Mote, Neva Scott, Gavin Hutchison, Eliana Choi, Helena Ventosa-Capell, Jiaqing Pang, Cristina Puy, Yabing Chen, Terry Morgan, Owen JT McCarty, Moua Yang, Michael Cohen, Joseph E Aslan
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 6, 2026, 16:03Professor Csongor Kiss Receives the Kálmán Laki Prize – Hungarian Society of Thrombosis and Haemostasis
-
Oct 6, 2026, 15:52Mark Kheifets: A Massive Stent Thrombosis Requiring Aspiration Thrombectomy
-
Oct 6, 2026, 15:36Nominations Open for ISTH Outstanding Mentor Awards – ISTH
-
Oct 6, 2026, 15:17Walaa Obaid: How Warfarin Went From Poison To Medicine
-
Oct 6, 2026, 15:16Nathan Hutchinson-Jones: Pharmacist-Led Care Optimises Cancer-Associated Thrombosis
-
Oct 6, 2026, 14:46Counting Down to WTD With a Focus on Thrombosis in Pregnancy
-
Oct 6, 2026, 14:29Jorge Enrique: Navigating Anticoagulation in Pregnancy With a Prosthetic Heart Valve
-
Oct 6, 2026, 14:20Hassan Abdelhak: Understanding How LVADs Support the Failing Heart
-
Oct 6, 2026, 14:04Breast Imaging Insights From Madrid – Swiss Journal of Radiology and Nuclear Medicine