Maria Carvajal Perea: Prothrombin Complex Concentrate vs Plasma – Optimizing Hemostasis After Cardiac Surgery
Maria Carvajal Perea, Basic Life Support for Healthcare Providers (BLS) at American Heart Association, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Colombian Journal of Anesthesiology, adding:
“I am thrilled to share the publication of my first scientific article as a co-author in the Colombian Journal of Anesthesiology!
‘Prothrombin complex concentrate versus plasma for coagulopathic bleeding after cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis.’
Managing coagulopathic bleeding after cardiac surgery requires rapid, evidence-based decisions. In this systematic review and meta-analysis, our team prioritized clinically relevant hemostatic outcomes rather than relying solely on surrogate laboratory markers.
Main Findings from Meta-Analysis:
- Hemostatic Control: Prothrombin complex concentrate (PCC) significantly reduced clinically relevant hemostatic failure compared to plasma strategies (RR 0.55; 95% CI 0.42–0.70).
- Renal Protection: PCC was associated with a lower risk of acute kidney injury (RR 0.57; 95% CI 0.35–0.91).
- Safety Profile: While results are promising, larger studies are still needed to more precisely define safety conclusions regarding thromboembolic events and mortality.
Being part of this inter-institutional project has been an incredibly valuable learning experience, further strengthening my commitment to research, academic medicine, and anesthesiology.
I’m very grateful to my co-authors and the entire research team for their invaluable scholarly guidance, rigorous feedback, and collaborative effort throughout this study.
Proud to see our work published.”
Title: Prothrombin complex concentrate versus plasma for coagulopathic bleeding after cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis
Authors: Paula A. Henríquez Miranda, Betty Gabriel Valencia Angarita, María Carvajal Perea, Mayra Alejandra Parada Navarro, Valentina Moreno Goyeneche, María Camila Madariaga Estupiñán
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