Mohamed Hesham Gamal: Intravenous Thrombolysis Shows Strong Safety Profile in Stroke Mimics
Mohamed Hesham Gamal, Medical Writer at Ray CRO, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Thrombosis and Thrombolysis, adding
“I am delighted to share that our systematic review and meta-analysis, ‘Safety and clinical outcomes of intravenous thrombolysis in stroke mimics compared with acute ischemic stroke: A systematic review and meta-analysis,’ has been published in the Journal of Thrombosis and Thrombolysis (Springer Nature, 2026; Q2, Impact Factor 2.1), where I had the honor of serving as the corresponding author.
Because door-to-needle times keep getting shorter, some patients with stroke mimics receive thrombolysis before the final diagnosis is confirmed.
We pooled 28 studies with about 285,000 patients. Compared with patients with acute ischemic stroke, patients with stroke mimics had much lower rates of symptomatic and any intracranial hemorrhage, lower in-hospital and 3-month mortality, better functional independence, more discharges home, and shorter hospital stays.
The reduction in hemorrhage was greatest in patients with milder deficits (NIHSS ≤ 7).
The key message: diagnostic uncertainty should not delay or withhold thrombolysis in otherwise eligible patients.
I am truly grateful to all my co-authors and colleagues for their valuable contributions, collaboration, and dedication throughout this work.
I hope this work supports confident, timely decision-making in hyperacute stroke care.”
Title: Safety and clinical outcomes of intravenous thrombolysis in stroke mimics compared with acute ischemic stroke: A systematic review and meta-analysis
Authors: Mohamed A. Khoudir, Usman Rashid, Abdelrahman A. Abdelhameed, Mohamed Hesham Gamal, Aranee Thirukketheesparan, Fajer Saleem, Ahmed A. Farag, Sara E. Elbahnasawy, Abdelrahman Mohamed, Hamood Qazi
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