Chengyong Yang: Can Plasma Reveal Cell Specific Signals
Chengyong Yang, Founder at Ascend Biosciences, shared Sarantis Chlamydas‘ post on LinkedIn:
“The interesting part here isn’t the clock – it’s that plasma can resolve cell-type signal at all.
Plasma is a bulk mixture.
Getting cell-specific information out of it only becomes possible once you’re measuring enough proteins that tissue-of-origin signatures start to separate.
That’s a threshold effect, and it’s why this kind of work wasn’t feasible with 50-plex panels a few years ago.
We run Olink panels day to day, and this is a good illustration of why breadth matters even when you think you know which proteins you care about.
The finding here isn’t in any single marker – it’s in the pattern across hundreds of them.
The open question, as with every aging clock: does it move when you intervene?
Cross-sectional association with chronological age is the easy part.
A clock that shifts in response to treatment is a different and much more valuable thing.”
Sarantis Chlamydas, Head of Human Health and MultiOmics Strategy at Thermo Fisher Scientific, shared a post on LinkedIn:
” What if we could measure how fast our cells are aging?
A new Nature Medicine study using Olink proteomics takes a major step in that direction developing protein-based clocks that capture aging at the cellular level.
The future of biological age may be cell-specific.”
Title: Plasma proteomic signatures of cellular aging predict human disease
Authors: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L. Chen, James W. Groves, Róbert Pálovics, Daisuke Masuda, Amelia Farinas, Hamilton Se-Hwee Oh, Viktoria Wagner, Nannan Lu, Carlos Cruchaga, Alina Isakova, Jonathan M. Schott, Tony Wyss-Coray
Stay uodated with Hemostasis Today.
-
Aug 12, 2026, 08:33Craig Clapper: What the Andrea Doria Collision Teaches Us About Safety
-
Aug 12, 2026, 07:49Alan Dursun: Phnom Penh, Cambodia – Part 3 – Turning Partnership into Action
-
Aug 12, 2026, 06:55Alejandro González Veliz: A Good PCI is not Just about Opening the Artery
-
Aug 12, 2026, 06:39Abdulmalik Alnuqydan: Why Do We Transfuse RBCs Less Than 7 Days Old to Newborns?
-
Aug 12, 2026, 06:24Lucas Jae: How Mitochondria Sense Heme Scarcity to Regulate Heme and Globin Production
-
Aug 12, 2026, 06:09Luis Tam։ New CDC Global Health Security Funding Opportunities
-
Aug 12, 2026, 06:09Yan Leyfman: Curative Strategies and Precision Medicine in Sickle Cell Disease
-
Aug 12, 2026, 06:01Sophie He: Exploring Manufacturing Scalability and Cell Separation
-
Aug 12, 2026, 05:54Yuan Goessi: One Bleed Is One Too Many for a Lifetime of Haemophilia A