Chengyong Yang: Can Plasma Reveal Cell Specific Signals
Chengyong Yang, Founder at Ascend Biosciences, shared Sarantis Chlamydas‘ post on LinkedIn, adding:
“The interesting part here isn’t the clock – it’s that plasma can resolve cell-type signal at all.
Plasma is a bulk mixture.
Getting cell-specific information out of it only becomes possible once you’re measuring enough proteins that tissue-of-origin signatures start to separate.
That’s a threshold effect, and it’s why this kind of work wasn’t feasible with 50-plex panels a few years ago.
We run Olink panels day to day, and this is a good illustration of why breadth matters even when you think you know which proteins you care about.
The finding here isn’t in any single marker – it’s in the pattern across hundreds of them.
The open question, as with every aging clock: does it move when you intervene?
Cross-sectional association with chronological age is the easy part.
A clock that shifts in response to treatment is a different and much more valuable thing.”
Sarantis Chlamydas, Head of Human Health and MultiOmics Strategy at Thermo Fisher Scientific, shared a post on LinkedIn:
“What if we could measure how fast our cells are aging?
A new Nature Medicine study using Olink proteomics takes a major step in that direction developing protein-based clocks that capture aging at the cellular level.
The future of biological age may be cell-specific.”
Title: Plasma proteomic signatures of cellular aging predict human disease
Authors: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L. Chen, James W. Groves, Róbert Pálovics, Daisuke Masuda, Amelia Farinas, Hamilton Se-Hwee Oh, Viktoria Wagner, Nannan Lu, Carlos Cruchaga, Alina Isakova, Jonathan M. Schott, Tony Wyss-Coray
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