François Saller: TFPI-Targeting VHHs for Haemophilia and Rare Bleeding Disorders
François Saller, Researcher in Hemostasis and Thrombosis at INSERM UMR-S1176, Assistant Professor in Hematology at Faculty of Pharmacy, Paris-Saclay University, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Thrombosis and Haemostasis, adding:
“Having just recovered from The Cure at Nimes Festival, I can now mention that our paper on anti-TFPI VHHs for rebalancing hemostasis in hemophilia and other rare bleeding disorders had finally been published in Thromb Haemost Thrombosis Haemostasis.
This project was initiated and co-led by Peter Lenting.
It really took off when a synthetic library of llama-derived VHHs generated at HITh lab Inserm by Ivan Peyron was used to identify our first functionally relevant VHHs.
Many more to come ?
Thanks to all the other co-authors with a special attention to Claire Auditeau, Elsa Bianchini, and Pradtahna Saenjamsai and Andréa Ruty for their pugnacity.”
Title: Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders
Authors: Claire Auditeau, Elsa P. Bianchini, Ivan Peyron, Andréa Ruty, Pradtahna Saenjamsai, Mariem Khamari, Tilman M. Hackeng, Olivier Christophe , Cecile V. Denis, Delphine Borgel, Peter J. Lenting, FranÇois Saller
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