Ihab Suliman/researchgate.net
Aug 18, 2026, 19:32
Ihab Suliman: A Snake Venom Helping Diagnose an Autoimmune Clotting Disorder?
Ihab Suliman, JA Assistant Professor and Consultant Advanced Cardiac Imaging at King Abdulaziz Medical City, shared a post on X:
“A snake venom helping diagnose an autoimmune clotting disorder?
Medicine is wild.
Russell’s viper venom directly activates Factor X.
In the dRVVT test, the venom triggers clotting – but the reaction still needs phospholipid.
Enter Lupus Anticoagulant.
It interferes with phospholipid-dependent clotting, so:
dRVVT becomes prolonged
Then the lab adds excess phospholipid…
The clotting time shortens. That strongly supports Lupus Anticoagulant.
And here is the paradox:
- In the lab, it looks like an anticoagulant
- In the patient, it can cause dangerous thrombosis
Snake venom. Autoantibodies. Blood clots. One elegant diagnostic test.”
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