Dr. S.0 MIKAYE/LinkedIn
Feb 9, 2026, 04:02
Samwel Mikaye: Signs of Iron Deficiency in Women
Samwel Mikaye, Medical Doctor at MSK, shared a post on LinkedIn:
“Signs of iron deficiency in women
Iron Deficiency (± Iron Deficiency Anaemia) — Clinical Signs
General / Constitutional
- Fatigue, lethargy
- Reduced exercise tolerance
- Weakness
- Syncope or presyncope (severe cases)
Cardiovascular and Respiratory
- Tachycardia
- Palpitations
- Dyspnoea on exertion
- Flow murmur (in anaemia)
Orthostatic hypotension (advanced)
Neurological & Cognitive
- Headache
- Dizziness
- Poor concentration
- Irritability
- Restless legs syndrome (common, often overlooked)
Dermatological
- Pallor (skin, conjunctiva, nail beds)
- Dry skin
- Hair thinning / alopecia
- Brittle nails
- Koilonychia (late sign)
Oral and Gastrointestinal
- Atrophic glossitis (smooth, beefy-red tongue)
- Angular cheilitis
- Dysphagia (Plummer–Vinson syndrome)
- Reduced appetite
- Pica (pagophagia common)
Immunological
- Increased susceptibility to infections
- Delayed wound healing
Gynaecological / Women-Specific
- Menorrhagia or prolonged menses (common cause and consequence)
- Fatigue disproportionate to Hb in reproductive-age women
- Pregnancy:
- Exaggerated fatigue
- Increased risk of preterm birth, low birth weight
- Postpartum fatigue not responding to rest
Laboratory Correlates
- Decreased Serum ferritin (earliest marker)
- Decreased Hb (late finding)
- Decreased MCV, decreased MCH (microcytic hypochromic anaemia)
- Increased RDW
- Decreased Serum iron
- Increased TIBC, Decreased transferrin saturation
- Normal or low reticulocyte count
Red Flags
- Iron deficiency without obvious blood loss
- Poor response to oral iron
- IDA in postmenopausal women
- Associated dysphagia or weight loss.”
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