Wolfgang Miesbach: Exploring the Role of Micronutrients in Healthy Longevity
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
“New RCT evidence says: possibly yes.
A large-scale randomized controlled trial — the COSMOS study — offers evidence that daily multivitamin–multimineral supplementation may modestly decelerate epigenetic aging in older adults:
Among 958 participants (mean age 70 years), 2 years of daily Centrum Silver — a standard multivitamin — significantly slowed the rise of well-validated epigenetic aging clocks (biological ‘speedometers’ derived from DNA methylation patterns that predict mortality risk).
Importantly, vitamins improved aging biomarkers: telomere length, and markers of cellular senescence, immune activation, and mitochondrial dysfunction.
The benefit was strongest in those with already accelerated biological aging at baseline — suggesting the greatest geroprotective effect in those who may need it most.
Interestingly, cocoa flavanol extract (500 mg/day) showed no significant effect on any of the five epigenetic clocks tested.
However, whether improvements in epigenetic clocks translate into meaningful clinical outcomes still needs to be confirmed in longer follow-up studies.
The authors propose that correcting subclinical micronutrient deficiencies may be the key driver — with likely even greater effects in less well-nourished populations.”
Other posts featuring Wolfgang Miesbach on Hemostasis Today.
-
May 22, 2026, 13:53Masoabi Sefojane: The Structural Invisibility of Bleeding Disorders in the Global South
-
May 22, 2026, 13:41Ney Carter Borges: New Trial Highlights IVL as Effective Strategy for Calcified Coronary Lesions
-
May 22, 2026, 13:36Ajay Samkaria։ A Compatible Crossmatch Does Not Always Mean Complete Safety
-
May 22, 2026, 13:31Mariam Swidan: Why Hemolysis Severity Matters in G6PD Deficiency
-
May 22, 2026, 13:25Augustina Isioma Ikusemoro: Why Plasma and RBC Transfusions Follow Different Compatibility Rules
-
May 22, 2026, 13:08Anas Hamad: Thrombosis as Overlooked Clinical Challenge in APL
-
May 22, 2026, 12:29Neema Ngugi: Highlighting 6 Major Types of Anemia
-
May 22, 2026, 12:27Jacinto López Sagaseta: Solving the Structural Puzzle of FVIIa–EPCR Interaction
-
May 22, 2026, 12:25Shehab Mohamed: Exploring the Emerging Link Between JAK2 Mutations and Thoracic Aortic Aneurysms