Yan Leyfman: Curative Strategies and Precision Medicine in Sickle Cell Disease
Yan Leyfman, Medical Oncologist, Co-Founder and Executive Director of MedNews Week, Medical Correspondent at OncLive, shared on LinkedIn about a recent article he and his colleagues co-authored, published in Encyclopedia, adding:
“For decades, a cure for sickle cell disease (SCD) depended on finding the right donor for an allogeneic stem cell transplant – a life-saving option that remained out of reach for many patients and carried the lifelong risk of graft-versus-host disease (GVHD).
Today, that paradigm is changing.
The emergence of autologous gene therapies, including Lyfgenia and Casgevy, has ushered in a new era of precision medicine, offering curative potential without the need for a donor or the risk of GVHD.
At the same time, advances in transplantation continue to expand access and improve outcomes, making treatment decisions more complex – and more exciting – than ever before.
In our new review, we explore:
- How stem cell transplantation has evolved over the past several decades
- The science and clinical data behind gene-editing and gene-addition therapies
- The strengths and limitations of each curative strategy
- The remaining barriers to affordability, accessibility, and global implementation
As curative therapies move from promise to clinical reality, understanding where the field stands – and where it’s headed – is essential for clinicians, researchers, and patients alike.”
Title: The New Era of Curative Therapies for Sickle Cell Disease: A Comprehensive Review of Allogeneic Transplantation and Autologous Gene Therapy
Authors: Ahmed Hashim Azeez, Sreesha Phani Durga Rithika Kodamanchili, Vraj JigarKumar Rangrej, Harshitha Vallabhaneni, Yan Leyfman, Adhith Theyver, Taha Kassim Dohadwala, Chandler Park
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