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Ahmed Koriesh: Stroke Prevention in the New 2026 ACC/AHA Dyslipidemia Guideline
Ahmed Koriesh/LinkedIn
Mar 16, 2026, 18:20

Ahmed Koriesh: Stroke Prevention in the New 2026 ACC/AHA Dyslipidemia Guideline

Ahmed Koriesh, Director of Hospital Neurology Service at Cleveland Clinic Florida, shared on LinkedIn:

”New 2026 ACC/AHA Dyslipidemia Guideline – What Neurologists Should Know

Stroke prevention is one of the areas most affected by the new lipid guidelines.

A few points stood out for neurologists:

  • Lower LDL is Better

For patients with established ASCVD (including ischemic stroke), the guideline reinforces aggressive LDL lowering — most stroke patients would qualify for <55 mg/dL target.

  • Earlier combination therapy

Rather than waiting months to escalate therapy, the guideline encourages earlier addition of ezetimibe or PCSK9 inhibitors when LDL targets are not reached.

  • Lp (a) is gaining attention

Measurement of lipoprotein(a) is now recommended at least once in many patients to better define inherited cardiovascular and stroke risk.

  • New lipid therapies are coming

Long-acting therapies targeting PCSK9 and emerging RNA-based treatments will help long-term lipid control in high-risk patients.

For neurologists, the guidelines leans towards more aggressive risk reduction.

For a clinical summary focused on stroke care.”

Ahmed Koriesh: Stroke Prevention in the New 2026 ACC/AHA Dyslipidemia Guideline

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