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Fariba Sarem and Colleagues Share Study About FAM132B Gene Expression in Beta-Thalassemia
Fariba Sarem/LinkedIn
Nov 5, 2025, 05:18

Fariba Sarem and Colleagues Share Study About FAM132B Gene Expression in Beta-Thalassemia

Fariba Sarem, International Affairs expert at Iranian Blood Transfusion Organization, posted on LinkedIn:

“Excited to announce the publication of my latest research in the International Journal of Hematology-Oncology and Stem Cell Research.
Title: Expression of the FAM132B Gene in Iranian Patients with Beta-Thalassemia
This study investigates the expression of the FAM132B gene, which encodes erythroferrone (ERFE), a key regulator of iron homeostasis, in Iranian patients with beta-thalassemia major (BTM) and intermedia (BTI).
Using SYBR Green-based real-time PCR  (RT-PCR), we analyzed gene expression in 40 thalassemia patients and 20 healthy controls. Our findings revealed:

  • Upregulation of FAM132B in BTI patients compared to BTM (p = 0.0151).
  • No significant difference between thalassemia patients (BTM & BTI) and healthy controls.

These results highlight differential ERFE expression across thalassemia subtypes and suggest the need for further research into its potential as a therapeutic target.

Grateful to my collaborators and mentors for their support throughout this project.”

Title: Expression of the FAM132B Gene in Iranian Patients with Beta-Thalassemia

Authors: Fariba Sarem, Azita Azarkeivan, Ahmad Mardani, Majid Shahabi

Fariba Sarem and Colleagues Share Study About FAM132B Gene Expression in Beta-Thalassemia

Read full paper here.

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Ahmad Mardani Azita Azarkeivan beta-thalassemia major (BTM) encodes erythroferrone (ERFE) FAM132B Fariba Sarem Health Hematology Hemostasis Hemostasis Today International Journal of Hematology-Oncology and Stem Cell Research Majid Shahabi Medicine
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