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Platelets Carry Tumor DNA! Powerful Potential for Liquid Biopsies and Precision Cancer Detection
Jean-Charles Soria/Academia Europea
Aug 17, 2025, 23:32

Platelets Carry Tumor DNA! Powerful Potential for Liquid Biopsies and Precision Cancer Detection

Jean-Charles Soria, Amgen’s senior vice president of Oncology within Global Development, posted on X:

”Platelets can carry tumor DNA.

  • Platelets – smallest yet 2nd most abundant blood cell type.
  • New study: tumor-derived DNA found in platelets of advanced cancer patients.
  • This cfDNA reservoir could complement plasma cfDNA, boosting detection sensitivity in low-tumor burden disease.
  • Platelets’ ubiquity, rapid turnover and vascular contact make them ideal biosensors for cancer and genetic alterations.
  • Findings carry broad implications for liquid biopsies and precision oncology.”

Read the full article here.

Article: Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA

Authors: Lauren Murphy, Jeanne Inchauspé, Giampiero Valenzano, Pamela Holland, Nikolaos Sousos, Hayley L. Belnoue-Davis, Rong Li, Natalie J. Jooss, Camelia Benlabiod, Eleanor Murphy, Zohar Etzioni, Emelie Shepherd, Lucy Denly, Sujata Biswas, Lin Chen, Jennifer O’Sullivan, Michael P. Rimmer, Abdullah O. Khan, Christina Simoglou Karali, Nadia Nasreddin, Ian S. Hitchcock, Milka Koupenova, Skirmantas Kriaucionis, Jim R. Hughes, Eric O’Neill, Manu Vatish, Paul Rees, Simon Leedham, Michael Desborough, Adam J. Mead, Benjamin Schuster-Böckler

Platelets Carry Tumor DNA! Powerful Potential for Liquid Biopsies and Precision Cancer Detection

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Abdullah O. Khan Adam J. Mead Amgen Benjamin Schuster-Böckler Camelia Benlabiod cancer cancer detection cfDNA Christina Simoglou Karali DNA Eleanor Murphy Emelie Shepherd Eric O’Neill genetic alterations Giampiero Valenzano Hayley L. Belnoue-Davis Health Hematology Hemostasis Today Ian S. Hitchcock Jeanne Inchauspé Jennifer O’Sullivan Jim R. Hughes Lauren Murphy Lin Chen Liquid Biopsy Lucy Denly Manu Vatish Medicine Michael Desborough Michael P. Rimmer Milka Koupenova Nadia Nasreddin Natalie J. Jooss Nikolaos Sousos Oncology Pamela Holland Paul Rees platelets precision oncology Rong Li Simon Leedham Skirmantas Kriaucionis Sujata Biswas Tumor Zohar Etzioni
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