Wolfgang Miesbach: Jan Astermark at the BIC 2025 Presented Potentially the First Oral FVIII Mimetic Treatment for Hemophilia A
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on Linkedin:
”For decades, oral protein delivery has failed.
Jan Astermark at the BIC meeting 2025 presented comprehensive information on oral factor VIII bispecific treatment for haemophilia A – potentially the first oral FVIII mimetic treatment!
Why is this so groundbreaking?
For decades, oral protein delivery has failed due to three major barriers:
- Large molecular size (poor absorption/bioavailability)
- GI instability (narrow pH tolerance, variable factors)
- High hydrophilicity (can’t cross membrane barriers)
This innovative Inno8 approach systematically addresses each challenge: ✨
- Optimized size (~30 kDa) via albumin binding technology
- Enhanced stability through protraction and pH optimization
- SNAC absorption enhancement for membrane permeability
- Extended half-life (115h terminal half-life!)
- Once-daily dosing potential with reduced variability
Inno8 successfully balances all critical aspects for an oral hemophilia drug – Size ✓ Potency ✓Stability ✓ PK ✓ – currently advancing through Phase 1 clinical trials for both patients with and without inhibitors.”
Stay updated on all coming congresses and seminars in the field of bleeding disorders with Hemostasis Today.
-
Apr 10, 2026, 18:22Chris Hillis: Reflections on My Term as President of the Canadian Hematology Society
-
Apr 10, 2026, 17:59Michelle Leona Cecil: Representing Microhealth at The Coalition for Hemophilia B Annual Symposium
-
Apr 10, 2026, 17:47Lucie Raskin: Comparing VTE Risk in Hormonal Contraceptives at NTHC 2026
-
Apr 10, 2026, 17:39Diverse Voices But Shared Mission – Day 1 of EHC Youth Leadership Workshop
-
Apr 10, 2026, 17:30Make Your Mark at the World Stroke Congress 2026 – World Stroke Organization
-
Apr 10, 2026, 17:23Sofie Abels: Implications for Targeted Screening for Thrombophilia in Young Stroke Patients
-
Apr 10, 2026, 17:08Armghan Ans: 3 Questions Worth Sitting with If You Work in Stroke AI
-
Apr 10, 2026, 17:03William Wallace: Vitamin C Is More Than ”Immune Support”
-
Apr 10, 2026, 16:58Wolfgang Miesbach: Greater Symptom Burden in Women with Bleeding Disorders – Insights from Irish Data