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ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway
Blood Journals Portfolio/X
Jul 28, 2025, 12:04

ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway

The Blood Journals Portfolio reported on its official X:

“ChAdOx1 induces platelet aggregation under shear via biomechanically activated integrin αIIbβ3, bypassing GPIb-dependent platelet adhesion pathway.”

Title: Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis

Authors: Yiyao Catherine Chen, Naveen Eugene Louis Richard Louis, Angela Huang, Allan Sun, Alexander Dupuy, Laura Moldovan, Tiana Pelaia, Jianfang Ren, Taylor S. Cohen, Sarah C. Gilbert, Huyen Tran, Karlheinz Peter, James D. McFadyen, Lining Arnold Ju

ChAdOx1 and Shear‑Dependent Platelet Aggregation: Uncovering a New Thrombotic Pathway

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Aggregation Alexander Dupuy Allan Sun Angela Huang ASH ASH Publications Blood Journals Portfolio Health Hematology Hemostasis Today Huyen Tran James D. McFadyen Jianfang Ren Karlheinz Peter Laura Moldovan Lining Arnold Ju Medicine Naveen Eugene Louis Richard Louis Platelet Sarah C. Gilbert Taylor S. Cohen Thrombotic Pathway Tiana Pelaia Yiyao Catherine Chen
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