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Amrit Kaur Kaler: The Hidden Genetic Drivers of Thrombosis
Amrit Kaur Kaler/LinkedIn, Sameer Tulpule/LinkedIn
Apr 30, 2026, 18:08

Amrit Kaur Kaler: The Hidden Genetic Drivers of Thrombosis

Amrit Kaur Kaler, Consultant in the Department of Genetics and Molecular Medicine at Kokilaben Dhirubhai Ambani Hospital, shared a post on LinkedIn about a recent article she and his colleagues co-authored, published in Journal of Thrombosis and Haemostasis, adding:

”Thrombophilia genetic polymorphisms are inherited variations in genes controlling blood coagulation, increasing the risk of venous and arterial thrombosis.

Common polymorphisms include Factor V Leiden (FVL 1691GA), Prothrombin (FII 20210GA), and MTHFR variants, which enhance clot formation or inhibit fibrinolysis. These genetic factors can cause hypercoagulable states, leading to VTE or reproductive issues.

Thanks to Dr R Sekhar, our vascular surgeon for sharing deep insights into the management of thrombosis. Thanks to Sameer Tulpule and all the authors for their contribution.”

Title: Re-evaluation of thrombophilia testing in clinical practice: Insights from an Indian cohort

Authors: Amrit Kaur Kaler​, Sameer Tulpule, Gaurav Mehta, Tushar Premraj Raut, Dattatray Solanke, Raghuram Sekhar, Vatsal Kothari, Subhash Aga

Amrit Kaur Kaler: The Hidden Genetic Drivers of Thrombosis

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Amrit Kaur Kaler Dattatray Solanke Gaurav Mehta Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today Medicine Raghuram Sekhar Sameer Tulpule Subhash Aga thrombosis Tushar Premraj Raut Vatsal Kothari
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