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Ana Lidia Flores-Mireles: Fibrin Suppresses Macrophage Defenses in Catheter-Associated UTIs
Ana Lidia Flores-Mireles/LinkedIn
Sep 27, 2026, 12:56

Ana Lidia Flores-Mireles: Fibrin Suppresses Macrophage Defenses in Catheter-Associated UTIs

Ana Lidia Flores-Mireles, Janet C. and Jeffrey A. Hawk Collegiate Associate Professor at University of Notre Dame, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Nature Communications, adding:

“New Paper Alert from our lab!

Ever wonder why catheter-associated UTIs are so persistent?

A fibrin-rich environment actively drives CAUTIs by suppressing key macrophage defenses.

Heroic effort led by Armando Marrufo with special thanks to specially to Christopher Gager, Jessica J. Kean, Katelyn C. Fealy and to all the co-authors!

Thanks to all our amazing collaborators Matthew Flick, Francis Castellino,Victoria Ploplis, and Felipe H Santiago Tirado!

Title: Fibrin-rich environment drives catheter-associated UTIs by suppressing macrophage defenses

Authors: Armando M. Marrufo, Christopher Gager, Jonathan J. Molina, Marissa J. Andersen, Alyssa A. La Bella, Jessica J. Kean, Katelyn C. Fealy, Elizabeth R. Lucas, Ellsa Wongso, Tamanna Urmi, Kassandra Arias-Parbul, Railyn Webster, Peter V. Stuckey, Kurt N. Kohler, Deborah Donahue, Victoria A. Ploplis, Matthew J. Flick, Francis J. Castellino, Felipe H. Santiago-Tirado, Ana L. Flores-Mireles

Ana Lidia Flores-Mireles: Fibrin Suppresses Macrophage Defenses in Catheter-Associated UTIs

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Alyssa A. La Bella Ana L. Flores-Mireles Ana Lidia Flores-Mireles antimicrobial defense Armando M. Marrufo Biomedical Research Catheter Infections Catheter-Associated UTI CAUTI Christopher Gager Deborah Donahue Elizabeth R. Lucas Ellsa Wongso Felipe H. Santiago-Tirado Fibrin Francis J. Castellino Hemostasis Hemostasis News Hemostasis Today Immunology Infection Research Innate Immunity Jessica J. Kean Jonathan J. Molina Kassandra Arias-Parbul Katelyn C. Fealy Kurt N. Kohler macrophages Marissa J. Andersen Matthew J. Flick Medical Research Microbiology Nature Communications Peter V. Stuckey Railyn Webster Tamanna Urmi Urinary Tract Infection Victoria A. Ploplis
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