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Arianna Giannetti: Ever Wondered If Mechanical Stretch Could Play a Role in DVT?
Arianna Giannetti/LinkedIn
Nov 17, 2025, 12:34

Arianna Giannetti: Ever Wondered If Mechanical Stretch Could Play a Role in DVT?

Arianna Giannetti, Postdoctoral Research Fellow at LadHyX École Polytechnique, shared on LinkedIn:

”Ever wondered if mechanical stretch could play a role in deep vein thrombosis (DVT)?

I am very happy to share that our paper “Uniaxial cyclic stretch regulates the expression of thrombomodulin and von Willebrand factor on endothelial cells” is now published in Blood VTH

During my PhD at the Centre de Biologie Structurale (Université de Montpellier), we explored how mechanical forces shape endothelial behavior.

Our key findings:
1. Continuous 10% cyclic stretch increases antithrombotic Thrombomodulin.
2. Interrupted stretch increases prothrombotic von Willebrand factor.

This suggests that how veins stretch might influence DVT mechanisms more than we thought.

Huge thanks to our amazing collaborators across Bordeaux, Nîmes, and Montpellier

And grateful for support from the ANR Programme Investissements d’Avenir.”

Read the full article here.

Article: Uniaxial cyclic stretch regulates the expression of thrombomodulin and von Willebrand factor on endothelial cells

Authors: Arianna Giannetti, Elisabeth Génot, Antonia Perez-Martin, Elsa Faure, Jean-Christophe Gris, Maïda Cardoso, Christophe Goze-Bac, Christine Benistant, Manouk Abkarian

Arianna Giannetti: Ever Wondered If Mechanical Stretch Could Play a Role in DVT?

Stay updated on all scientific advances in the field of thrombosis with Hemostasis Today.

Antonia Perez-Martin Arianna Giannetti bleeding disorders blood VTH Christine Benistant Christophe Goze-Bac DVT Elisabeth Génot Elsa Faure Health Hematology Hemostasis Hemostasis Today Jean-Christophe Gris LadHyX École Polytechnique Maïda Cardoso Manouk Abkarian Medicine Thrombomodulin thrombosis Université de Montpellier VWD VWF
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