Chien-Wen Liew: Where PRP Actually Sits in the Evidence
Chien-Wen Liew, Adjunct Professor at University of the Sunshine Coast, Orthopaedic Surgeon at Orthopaedics 360, shared a post on LinkedIn:
“A 2025 meta-analysis of 18 randomised trials covering 1,995 patients found platelet rich plasma produced better pain and function scores than placebo for up to 12 months, with clinically relevant improvements at three and six months.
That is a more favourable evidence base than hyaluronic acid currently has, and it deserves to be stated accurately rather than dismissed.
Two qualifications matter. PRP is symptom modifying, not cartilage regenerating. Nothing in the data supports the claim that it rebuilds cartilage, and patients are frequently sold it on that basis.
Second, preparation protocols vary enormously between providers. That heterogeneity is the main reason PRP has not become standard of care despite reasonable trial results. Two products called PRP may have very different platelet concentrations and leukocyte content.
The same three month pre-operative window applies to PRP as to steroid.”
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