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C-Reactive Protein and Cardiovascular Risk in the General Population: A European Heart Journal Study by Berkan Kurt et al.
Berkan Kurt/LinkedIn
Dec 12, 2025, 23:37

C-Reactive Protein and Cardiovascular Risk in the General Population: A European Heart Journal Study by Berkan Kurt et al.

Berkan Kurt, Resident Physician in Cardiology and Internal Medicine at Uniklinik RWTH Aachen, posted on LinkedIn:

“Deeply grateful to share that our article “C-reactive protein and cardiovascular risk in the general population” has now been published in the European Heart Journal.

In 448 653 adults without known ASCVD, a single hsCRP measurement showed strong stability over time, displayed long-term inflammatory risk, and independently predicted MACE, CV death and all-cause mortality across clinically relevant subgroups, including SMuRF-less but inflamed individuals. hsCRP ranked among the strongest predictors of CV outcomes and added incremental value to SCORE2-based risk prediction. C-Reactive Protein and Cardiovascular Risk in the General Population: A European Heart Journal Study by Berkan Kurt et al.

Our findings underscore residual inflammatory risk as an additional, relevant dimension in primary prevention. Routine hsCRP assessment should be considered for inclusion in future guidelines to refine CV risk assessment and to improve prevention strategies in patients without a history of ASCVD.

Sincerely thankful to my mentor Florian Kahles for his continuous support and guidance, my colleague Martin Reugels for the outstanding work together on this project, and to all co-authors and international colleagues for their generous collaboration and the privilege of working together with leading experts in the field.

Open access article”

Title: C-reactive protein and cardiovascular risk in the general population

Authors: Berkan Kurt, Martin Reugels, Kai M Schneider, Jens Spiesshoefer, Andrea Milzi, Alexander Gombert, Christopher B Fordyce, Florian A Wenzl, Neha J Pagidipati, Viviane Rocha, Marat Fudim, Abhinav Sharma, Michael Lehrke, Hiroaki Shimokawa, Giovanna Liuzzo, Lale Tokgozoglu, Filippo Crea, Thomas F Lüscher, Peter Libby, Paul M Ridker, Nikolaus Marx, Carolin V Schneider, Florian Kahles

C-Reactive Protein and Cardiovascular Risk in the General Population: A European Heart Journal Study by Berkan Kurt et al.

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Abhinav Sharma Alexander Gombert Andrea Milzi ASCVD Berkan Kurt Carolin V Schneider Christopher B. Fordyce CV Risk European Heart Journal Filippo Crea Florian A Wenzl Florian Kahles Giovanna Liuzzo Health Hematology Hemostasis Hemostasis Today Hiroaki Shimokawa hsCRP Jens Spiesshoefer Kai M Schneider Lale Tokgözoğlu MACE Marat Fudim Martin Reugels Medicine Michael Lehrke Neha J Pagidipati Nikolaus Marx Paul M Ridker Peter Libby Thomas F Lüscher Viviane Rocha
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